ArticleHuman heredity2006
Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene cluster.
Article in Human heredity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Long-range linkage disequilibrium in French beef cattle breeds.Genetics, selection, evolution : GSE · 2021Article
- Candidate genes for predicting the survival of patients with gastric cancer: a study based on The Cancer Genome Atlas (TCGA) database.Translational cancer research · 2020Article
- Article
- The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits.Scientific reports · 2017Article
- Association of the SPT2 chromatin protein domain containing 1 gene rs17579600 polymorphism and serum lipid traits.International journal of clinical and experimental pathology · 2015Article
- Re-sequencing of the APOAI promoter region and the genetic association of the -75G > A polymorphism with increased cholesterol and low density lipoprotein levels among a sample of the Kuwaiti population.BMC medical genetics · 2013Article
- Long range linkage disequilibrium across the human genome.PloS one · 2013Article
- Minor allele of the APOA4 gene T347S polymorphism predisposes to obesity in postmenopausal Turkish women.Molecular biology reports · 2012Article
- Single nucleotide polymorphism barcoding to evaluate oral cancer risk using odds ratio-based genetic algorithms.The Kaohsiung journal of medical sciences · 2012Article
- Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol.Atherosclerosis · 2012Article
- Associations of polymorphisms in the apolipoprotein APOA1-C3-A5 gene cluster with acute coronary syndrome.Journal of biomedicine & biotechnology · 2012Article
- The APOA1/C3/A4/A5 cluster and markers of allostatic load in the Boston Puerto Rican Health Study.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2011Article
- Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels.Lipids in health and disease · 2011Article
- Performance of single nucleotide polymorphisms versus haplotypes for genome-wide association analysis in barley.PloS one · 2010Article
- Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.Human molecular genetics · 2010Article
- Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men.Journal of lipid research · 2010Article
- Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease.Lipids in health and disease · 2008Article
- Linkage disequilibrium--understanding the evolutionary past and mapping the medical future.Nature reviews. Genetics · 2008Review
- Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: a case for dimensionality reduction?Mutation research · 2007Review
- The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL-C variability.Journal of molecular medicine (Berlin, Germany) · 2006Article
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7 authors.
Funding
Abstract
objectiveEvaluate the consistency of the contribution of interactions between single nucleotide polymorphism (SNP) genotype effects to variation in measures of lipid metabolism across ethnic strata within gender. METHODS AND
resultsWe considered 80 SNPs within the apolipoprotein (APO) A1/C3/A4/A5 gene cluster using an over-parameterized general linear model to identify SNPs whose genotype effects combine non-additively to influence plasma levels of high density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG) in a consistent manner across ethnic strata. We analyzed population-based samples of unrelated 18 to 30 year old African-Americans (n = 1,858) and European-Americans (n = 1,973) ascertained without regard to health at four field centers (Birmingham, Ala.; Chicago, Ill.; Minneapolis, Minn. and Oakland, Calif., USA) by the Coronary Artery Risk Development in Young Adults (CARDIA) study. To identify which SNP genotype effects combine non-additively we used a two-tier analysis strategy. We first required that pairs of SNPs show statistically significant non-additivity in both ethnic strata within a gender, where experiment-wise significance was evaluated using a permutation test to determine the probability of observing the number of tests significant in both ethnic strata by chance alone. Second, we required no significant evidence of heterogeneity of the relationship between the phenotype and the two SNP genotypes across ethnic strata and across field centers within each ethnic group. From this strategy we identified ten pairs of SNPs, involving thirteen SNPs, that displayed statistically significant non-additivity of SNP genotype effects on TC. Only one of these thirteen SNPs had statistically significant genotype effects that were consistent across samples.
conclusionOur analyses suggest that ignoring the contribution of interactions between SNP genotype effects when modeling multi-SNP genotype-phenotype relationships may result in an underestimate of the contribution of genetic variation to variation in quantitative cardiovascular disease (CVD) risk factor traits.
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