ArticleJournal of immunology (Baltimore, Md. : 1950)2006
Clustering class I MHC modulates sensitivity of T cell recognition.
Article in Journal of immunology (Baltimore, Md. : 1950), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- Proximity proteome mapping reveals PD-L1-dependent pathways disrupted by anti-PD-L1 antibody specifically in EGFR-mutant lung cancer cells.Cell communication and signaling : CCS · 2023Article
- Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells.Cellular and molecular life sciences : CMLS · 2022Article
- Homotypic and heterotypicCurrent research in immunology · 2022Review
- N-Linked Glycosylation Regulates CD22 Organization and Function.Frontiers in immunology · 2019Article
- Precision engineering of targeted nanocarriers.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- Engineering Platforms for T Cell Modulation.International review of cell and molecular biology · 2018Review
- Biologically Inspired Design of Nanoparticle Artificial Antigen-Presenting Cells for Immunomodulation.Nano letters · 2017Article
- Molecular characterization of MHC class II in the Australian invasive cane toad reveals multiple splice variants.Immunogenetics · 2016Article
- Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling.The Journal of cell biology · 2016Review
- Engineering macrophages to control the inflammatory response and angiogenesis.Experimental cell research · 2015Article
- A high fat diet containing saturated but not unsaturated fatty acids enhances T cell receptor clustering on the nanoscale.Prostaglandins, leukotrienes, and essential fatty acids · 2015Article
- The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex.European journal of immunology · 2015Article
- Linking form to function: Biophysical aspects of artificial antigen presenting cell design.Biochimica et biophysica acta · 2015Review
- Organizing MHC Class II Presentation.Frontiers in immunology · 2014Review
- Mapping the local organization of cell membranes using excitation-polarization-resolved confocal fluorescence microscopy.Biophysical journal · 2013Article
- T cell activation is determined by the number of presented antigens.Nano letters · 2013Article
- Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes.PloS one · 2012Article
- Probing orientational behavior of MHC class I protein and lipid probes in cell membranes by fluorescence polarization-resolved imaging.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
T cell recognition of peptide-MHC is highly specific and is sensitive to very low levels of agonist peptide; however, it is unclear how this effect is achieved or regulated. In this study we show that clustering class I MHC molecules on the cell surface of B lymphoblasts enhances their recognition by mouse and human T cells. We increased clustering of MHC I molecules by two methods, cholesterol depletion and direct cross-linking of a dimerizable MHC construct. Imaging showed that both treatments increased the size and intensity of MHC clusters on the cell surface. Enlarged clusters correlated with enhanced lysis and T cell effector function. Enhancements were peptide-specific and greatest at low concentrations of peptide. Clustering MHC class I enhanced recognition of both strong and weak agonists but not null peptide. Our results indicate that the lateral organization of MHC class I on the cell surface can modulate the sensitivity of T cell recognition of agonist peptide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.