ArticleHeart (British Cardiac Society)2006
Distribution of SPARC during neovascularisation of degenerative aortic stenosis.
Article in Heart (British Cardiac Society), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01679431 (Metabolic Determinants of the Progression of Aortic Stenosis - PROGRESSA Study), which is not on this map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolic Determinants of the Progression of Aortic Stenosis - PROGRESSA Study
Who cites it
36 citing papers in PubMed, 90 citations in OpenAlex.
- Hemodynamic phenotypes of severe aortic stenosis in patients with small aortic annulus and implications for transcatheter aortic valve implantation outcomes.Cardiovascular intervention and therapeutics · 2026Article
- Calcific aortic valve disease: mechanisms, prevention and treatment.Nature reviews. Cardiology · 2023Review
- Trans-Aortic Flow Turbulence and Aortic Valve Inflammation: A Pilot Study Using Blood Speckle Imaging andJournal of cardiovascular imaging · 2023Article
- Bioprosthetic heart valve structural degeneration associated with metabolic syndrome: Mitigation with polyoxazoline modification.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Hypoxia-inducible factor activation promotes osteogenic transition of valve interstitial cells and accelerates aortic valve calcification in a mice model of chronic kidney disease.Frontiers in cardiovascular medicine · 2023Article
- Role of oxidative stress in calcific aortic valve disease and its therapeutic implications.Cardiovascular research · 2022Review
- Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management?Non-coding RNA research · 2020Review
- Association Between Serum Leptin Level and Calcific Aortic Valve Disease.Journal of the American Heart Association · 2019Article
- Ectopic mineralization in heart valves: new insights fromJournal of thoracic disease · 2019Review
- SPARC inhibits breast cancer bone metastasis and may be a clinical therapeutic target.Oncology letters · 2017Article
- Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis.PloS one · 2017Article
- SPARC expression by cerebral microvascular endothelial cells in vitro and its influence on blood-brain barrier properties.Journal of neuroinflammation · 2016Article
- The role of secreted protein acidic and rich in cysteine (SPARC) in cardiac repair and fibrosis: Does expression of SPARC by macrophages influence outcomes?Journal of molecular and cellular cardiology · 2016Review
- Calcific aortic stenosis.Nature reviews. Disease primers · 2016Review
- Osteopontin is proteolytically processed by matrix metalloproteinase 9.Canadian journal of physiology and pharmacology · 2015Article
- The pathology and pathobiology of bicuspid aortic valve: State of the art and novel research perspectives.The journal of pathology. Clinical research · 2015Article
- Regulation of valve endothelial cell vasculogenic network architectures with ROCK and Rac inhibitors.Microvascular research · 2015Article
- Innate and Adaptive Immunity in Calcific Aortic Valve Disease.Journal of immunology research · 2015Review
- Effect of Oxidized Low Density Lipoprotein on the Expression of Runx2 and SPARC Genes in Vascular Smooth Muscle Cells.Iranian biomedical journal · 2015Article
- Calcific Aortic Valve Disease: Molecular Mechanisms and Therapeutic Approaches.European cardiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the hypothesis that degenerative aortic stenosis (AS) is associated with the development of blood vessels and the expression of the secreted protein, acidic and rich in cysteine/osteonectin (SPARC), a matricellular protein that is involved in ossification, the modulation of angiogenesis and the production of metalloproteinases.
methods30 surgically excised AS valves and 20 normal aortic valves were studied.
resultsBlood vessels were detected in the aortic valves from patients with degenerative AS, whereas normal valves were avascular structures. Blood vessels in AS valves expressed endothelial nitric oxide synthase, CD34 and von Willebrand factor (vWF). Blood vessels were located in three distinct regions: near calcified nodules, under the leaflet border and in rich cellular areas forming cell islands. Blood vessels were predominantly present in early and intermediate grades of calcification. Cell islands were densely populated by CD45-positive cells where endothelial cells (CD34+, vWF+) forming cord-like structures were present. Immunoblotting detected SPARC only in AS valves and immunohistological analysis located SPARC in mature blood vessels. The proportion of blood vessels positive for SPARC was higher in valves with a lower grade of calcification. In cell islands, SPARC was distributed to mature blood vessels and to macrophages, where it co-located with matrix metalloproteinase-9, whereas no expression was detected in endothelial cells forming cord-like structures.
conclusionThe localisation of SPARC to mature blood vessels and its predominant expression in AS valves with a lower calcification grade suggest that the spatial and temporal distribution of this matricellular protein is tightly controlled to participate in the neovascularisation of AS valves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.