ArticleLipids in health and disease2006
Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans.
Article in Lipids in health and disease, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Pooled it
- Timing and duration of calorie restriction determine its impact on ovarian aging in female mice.npj aging · 2025Article
- Nutrition, GH/IGF-1 signaling, and cancer.Endocrine-related cancer · 2024Review
- Sex-specific effects of dietary restriction on physiological variables in Japanese quails.Ecology and evolution · 2024Article
- AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences.Cell reports · 2023Article
- Ketogenic diet enhances the effects of oxycodone in mice.Scientific reports · 2023Article
- Assessment of circulating extracellular vesicles from calorie-restricted mice and humans in ischaemic injury models.Journal of extracellular biology · 2023Article
- Metabolic management of microenvironment acidity in glioblastoma.Frontiers in oncology · 2022Review
- Effects of cigarette smoke exposure on a mouse model of multiple sclerosis.Toxicology reports · 2022Article
- Chronic exogenous ketone supplementation blunts the decline of cardiac function in the failing heart.ESC heart failure · 2021Article
- Diabetes medications as potential calorie restriction mimetics-a focus on the alpha-glucosidase inhibitor acarbose.GeroScience · 2021Article
- Metabolic Regulation of Stem Cells in Aging.Current stem cell reports · 2021Article
- Transcriptomic Effects of Healthspan-Promoting Dietary Interventions: Current Evidence and Future Directions.Frontiers in nutrition · 2021Review
- Health Effects of Alternate Day Fasting Versus Pair-Fed Caloric Restriction in Diet-Induced Obese C57Bl/6J Male Mice.Frontiers in physiology · 2021Article
- Consideration of Ketogenic Metabolic Therapy as a Complementary or Alternative Approach for Managing Breast Cancer.Frontiers in nutrition · 2020Review
- Preconditioning with partial caloric restriction confers long-term protection against grey and white matter injury after transient focal ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension.Cell reports · 2018Article
- Effects of food restriction on the expression of genes related to acetaminophen-induced liver toxicity in rats.Journal of toxicologic pathology · 2018Article
- Application of Bayesian evidence synthesis to modelling the effect of ketogenic therapy on survival of high grade glioma patients.Theoretical biology & medical modelling · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCaloric restriction (CR) has long been recognized as a dietary therapy that improves health and increases longevity. Little is known about the persistent effects of CR on plasma biomarkers (glucose, ketone bodies, and lipids) following re-feeding in mice. It is also unclear how these biomarker changes in calorically restricted mice relate to those observed previously in calorically restricted humans.
resultsThree groups of individually housed adult female C57BL/6J (B6) mice (n = 4/group) were fed a standard rodent chow diet either: (1) unrestricted (UR); (2) restricted for three weeks to reduce body weight by approximately 15-20% (R); or (3) restricted for three weeks and then re-fed unrestricted (ad libitum) for an additional three weeks (R-RF). Body weight and food intake were measured throughout the study, while plasma lipids and levels of glucose and ketone bodies (beta-hydroxybutyrate) were measured at the termination of the study. Plasma glucose, phosphatidylcholine, cholesterol, and triglycerides were significantly lower in the R mice than in the UR mice. In contrast, plasma fatty acids and beta-hydroxybutyrate were significantly higher in the R mice than in the UR mice. CR had no effect on plasma phosphatidylinositol levels. While body weight and plasma lipids of the R-RF mice returned to unrestricted levels upon re-feeding, food intake and glucose levels remained significantly lower than those prior to the initiation of CR.
conclusionCR establishes a new homeostatic state in B6 mice that persists for at least three weeks following ad libitum re-feeding. Moreover, the plasma biomarker changes observed in B6 mice during CR mimic those reported in humans on very low calorie diets or during therapeutic fasting.
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Registered trials
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