ArticleBMC genetics2006
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.
Article in BMC genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis.Liver research (Beijing, China) · 2020Article
- Chitooligosaccharides Modulate Glucose-Lipid Metabolism by Suppressing SMYD3 Pathways and Regulating Gut Microflora.Marine drugs · 2020Article
- Genes Potentially Associated with Familial Hypercholesterolemia.Biomolecules · 2019Review
- Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression.Circulation. Genomic and precision medicine · 2018Article
- Genetic Variations Associated with Anti-Tuberculosis Drug-Induced Liver Injury.Current pharmacology reports · 2018Article
- Diurnal variation in cholesterol 7α-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene.Croatian medical journal · 2016Article
- CYP7A1 gene polymorphism located in the 5' upstream region modifies the risk of coronary artery disease.Disease markers · 2015Article
- The CYP7A1 gene rs3808607 variant is associated with susceptibility of tuberculosis in Moroccan population.The Pan African medical journal · 2014Article
- The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate.Journal of cardiovascular pharmacology · 2012Article
- Allelic polymorphism detected in the bovine FTO gene.Molecular biotechnology · 2011Article
- Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population.Genetics and molecular biology · 2011Article
- Ethnic differences in the prevalence of polymorphisms in CYP7A1, CYP7B1 AND CYP27A1 enzymes involved in cholesterol metabolism.Journal of pharmacy & bioallied sciences · 2011Article
- SNP discovery and haplotype analysis in the bovine PRKAA2 gene.Molecular biology reports · 2011Article
- Association between CYP7A1 and the risk of proximal colon cancer in Japanese.International journal of molecular epidemiology and genetics · 2010Article
- Single nucleotide polymorphisms and haplotypic diversity in the bovine PRKAB1 gene.Molecular biotechnology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids. Genetic variations in the CYP7A1 gene have been associated with metabolic disorders of cholesterol and bile acids, including hypercholesterolemia, hypertriglyceridemia, arteriosclerosis, and gallstone disease. Current genetic studies are focused mainly on analysis of a single nucleotide polymorphism (SNP) at A-278C in the promoter region of the CYP7A1 gene. Here we report a genetic approach for an extensive analysis on linkage disequilibrium (LD) blocks and haplotype structures of the entire CYP7A1 gene and its surrounding sequences in Africans, Caucasians, Asians, Mexican-Americans, and African-Americans.
resultThe LD patterns and haplotype blocks of CYP7A1 gene were defined in Africans, Caucasians, and Asians using genotyping data downloaded from the HapMap database to select a set of haplotype-tagging SNPs (htSNP). A low cost, microarray-based platform on thin-film biosensor chips was then developed for high-throughput genotyping to study transferability of the HapMap htSNPs to Mexican-American and African-American populations. Comparative LD patterns and haplotype block structure was defined across all test populations.
conclusionA constant genetic structure in CYP7A1 gene and its surrounding sequences was found that may lead to a better design for association studies of genetic variations in CYP7A1 gene with cholesterol and bile acid metabolism.
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