ArticleMechanics & chemistry of biosystems : MCB2005
Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors.
Article in Mechanics & chemistry of biosystems : MCB, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Micropillars in Cell Mechanobiology: Design, Fabrication, Characterization, and Biosensing Applications.Small science · 2025Review
- Measuring the biomechanical properties of cell-derived fibronectin fibrils.Biomechanics and modeling in mechanobiology · 2025Article
- Bayesian traction force estimation using cell boundary-dependent force priors.Biophysical journal · 2023Article
- Fungus-derived protein particles as cell-adhesive matrices for cell-cultivated food.NPJ science of food · 2023Article
- Article
- Revisiting tissue tensegrity: Biomaterial-based approaches to measure forces across length scales.APL bioengineering · 2021Review
- Rheological characterization of poly-dimethyl siloxane formulations with tunable viscoelastic properties.RSC advances · 2021Article
- Human mammary epithelial cells in a mature, stratified epithelial layer flatten and stiffen compared to single and confluent cells.Biochimica et biophysica acta. General subjects · 2021Article
- Effects of substrate stiffness and actin velocity on in silico fibronectin fibril morphometry and mechanics.PloS one · 2021Article
- A discrete interface in matrix stiffness creates an oscillatory pattern of endothelial monolayer disruption.Journal of cell science · 2020Article
- Cellogram: On-the-Fly Traction Force Microscopy.Nano letters · 2019Article
- T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Measure and characterization of the forces exerted by growing multicellular spheroids using microdevice arrays.PloS one · 2019Article
- Effect of Terminal Modification on the Molecular Assembly and Mechanical Properties of Protein-Based Block Copolymers.Macromolecular bioscience · 2017Article
- Review of cellular mechanotransduction on micropost substrates.Medical & biological engineering & computing · 2016Review
- Data on cell spread area and directional contraction in human umbilical vein endothelial cells on fibronectin and on collagen type I-coated micro-posts.Data in brief · 2016Article
- Micro- and nanodevices integrated with biomolecular probes.Biotechnology advances · 2015Review
- Easy and Accurate Mechano-profiling on Micropost Arrays.Journal of visualized experiments : JoVE · 2015Article
- Fibronectin fibrillogenesis facilitates mechano-dependent cell spreading, force generation, and nuclear size in human embryonic fibroblasts.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Protrusive and Contractile Forces of Spreading Human Neutrophils.Biophysical journal · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The interplay of mechanical forces between the extracellular environment and the cytoskeleton drives development, repair, and senescence in many tissues. Quantitative definition of these forces is a vital step in understanding cellular mechanosensing. Microfabricated post array detectors (mPADs) provide direct measurements of cell-generated forces during cell adhesion to extracellular matrix. A new approach to mPAD post labeling, volumetric imaging, and an analysis of post bending mechanics determined that cells apply shear forces and not point moments at the matrix interface. In addition, these forces could be accurately resolved from post deflections by using images of post tops and bases. Image analysis tools were then developed to increase the precision and throughput of post centroid location. These studies resulted in an improved method of force measurement with broad applicability and concise execution using a fully automated force analysis system. The new method measures cell-generated forces with less than 5% error and less than 90 seconds of computational time. Using this approach, we demonstrated direct and distinct relationships between cellular traction force and spread cell surface area for fibroblasts, endothelial cells, epithelial cells and smooth muscle cells.
Indexed as
Identifiers
16708468PMC1480360What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.