ArticleEuropean journal of immunology2006
Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance.
Article in European journal of immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 71 citations in OpenAlex.
- Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1.The AAPS journal · 2019Trial
- Tolerance-inducing therapies in coeliac disease - mechanisms, progress and future directions.Nature reviews. Gastroenterology & hepatology · 2024Review
- The immune checkpoint ICOSLG is a relapse-predicting biomarker and therapeutic target in infant t(4;11) acute lymphoblastic leukemia.iScience · 2022Article
- Antigen-specific immunotherapy with apitopes suppresses generation of FVIII inhibitor antibodies in HLA-transgenic mice.Blood advances · 2022Article
- Advancement of antigen-specific immunotherapy: knowledge transfer between allergy and autoimmunity.Immunotherapy advances · 2021Review
- Development of a Prognostic Model for Ovarian Cancer Patients Based on Novel Immune Microenvironment Related Genes.Frontiers in oncology · 2021Article
- PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor.Science signaling · 2020Article
- A Risk Prediction Model for Breast Cancer Based on Immune Genes Related to Early Growth Response Proteins Family.Frontiers in molecular biosciences · 2020Article
- Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.Immunity, inflammation and disease · 2018Article
- Early Growth Response Gene 2-Expressing CD4Frontiers in immunology · 2018Review
- Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.The Journal of experimental medicine · 2017Article
- Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells.Journal of neuroinflammation · 2016Article
- On Peptides and Altered Peptide Ligands: From Origin, Mode of Action and Design to Clinical Application (Immunotherapy).International archives of allergy and immunology · 2016Review
- Tr1-Like T Cells - An Enigmatic Regulatory T Cell Lineage.Frontiers in immunology · 2016Article
- Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells.Journal of neuroinflammation · 2015Article
- MHC Class II-Restricted Epitopes Containing an Oxidoreductase Activity Prompt CD4(+) T Cells with Apoptosis-Inducing Properties.Frontiers in immunology · 2015Review
- Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.Nature communications · 2014Article
- The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype.International journal for parasitology · 2013Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Repetitive antigen stimulation induces peripheral T cell tolerance in vivo. It is not known, however, whether multiple stimulations merely suppress T cell activation or, alternatively, change the transcriptional program to a distinct, tolerant state. In this study, we have discovered that STAT3 and STAT5 were activated in response to antigen stimulation in vivo, in marked contrast to the suppression of AP-1, NF-kappaB and NFAT. In addition, a number of transcription factors were induced in tolerant T cells following antigen challenge in vivo, including T-bet, Irf-1 and Egr-2. The altered transcription program in tolerant cells associates closely with the suppression of cell cycle progression and IL-2 production, as well as with the induction of IL-10. Studies of T-bet and Egr-2 show that the function of T-bet in peptide treatment-induced regulatory T cells is not associated with Th1 differentiation, but correlates with the suppression of IL-2, whereas expression of Egr-2 led to an up-regulation of the cell cycle inhibitors p21(cip1) and p27(kip). Our results demonstrate a balanced transcription program regulated by different transcription factors for T cell activation and/or tolerance during antigen-induced T cell responses. Persistent antigen stimulation can induce T cell tolerance by changing the balance of transcription factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.