ReviewNature reviews. Genetics2006
The quest for genetic determinants of human longevity: challenges and insights.
Review in Nature reviews. Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
209 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Glucocorticoid resistance and β2-adrenergic receptor signaling pathways promote peripheral pro-inflammatory conditions associated with chronic psychological stress: A systematic review across species.Neuroscience and biobehavioral reviews · 2021Pooled it
- GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Pooled it
- Pooled it
- Pooled it
- Genetic, physiological, and lifestyle predictors of mortality in the general population.American journal of public health · 2012Pooled it
- A genome-wide association study of aging.Neurobiology of aging · 2011Pooled it
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.Aging cell · 2011Pooled it
- Circulating microRNA responses to acute whole-body vibration and resistance exercise in postmenopausal women.Frontiers in endocrinology · 2022Trial
- Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing.Mechanisms of ageing and development · 2013Trial
- Trial
- Genomic comparisons and the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew.Molecular biology and evolution · 2026Article
- An integrated multi-omic natural history study of human development, sexual dimorphism, and the effects of trisomy 21.Nature communications · 2025Article
- The Bitemporal Lens Model-toward a holistic approach to chronic disease prevention with digital biomarkers.JAMIA open · 2024Review
- Longevity-CancerDB: unlocking the distinctive features and roles of longevity-associated genes in tumourigenesis.Clinical and translational medicine · 2024Article
- Unveiling recent and ongoing adaptive selection in human populations.PLoS biology · 2024Article
- The rosetta stone of successful ageing: does oral health have a role?Biogerontology · 2023Review
- Article
- Advancing methods for the biodemography of aging within social contexts.Neuroscience and biobehavioral reviews · 2023Review
- Which Factors Influence Healthy Aging? A Lesson from the Longevity Village of Bama in China.Aging and disease · 2023Review
- Genetic Networks of Alzheimer's Disease, Aging, and Longevity in Humans.International journal of molecular sciences · 2023Article
149 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Twin studies show that genetic differences account for about a quarter of the variance in adult human lifespan. Common polymorphisms that have a modest effect on lifespan have been identified in one gene, APOE, providing hope that other genetic determinants can be uncovered. However, although variants with substantial beneficial effects have been proposed to exist and several candidates have been put forward, their effects have yet to be confirmed. Human studies of longevity face numerous theoretical and logistical challenges, as the determinants of lifespan are extraordinarily complex. However, large-scale linkage studies of long-lived families, longitudinal candidate-gene association studies and the development of analytical methods provide the potential for future progress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.