ArticleJournal of bacteriology2006
The superoxide dismutases of Bacillus anthracis do not cooperatively protect against endogenous superoxide stress.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Why is manganese so valuable to bacterial pathogens?Frontiers in cellular and infection microbiology · 2023Review
- ExsY, CotY, and CotE Effects on Bacillus anthracis Outer Spore Layer Architecture.Journal of bacteriology · 2022Article
- Isocitrate dehydrogenase of Bacillus cereus is involved in biofilm formation.World journal of microbiology & biotechnology · 2021Article
- Four superoxide dismutases of Bacillus cereus 0-9 are non-redundant and perform different functions in diverse living conditions.World journal of microbiology & biotechnology · 2020Article
- Roles of the Two-MnSOD System ofInternational journal of molecular sciences · 2019Article
- Potential of 2, 2'-dipyridyl diselane as an adjunct to antibiotics to manage cadmium-induced antibiotic resistance in Salmonella enterica serovar Typhi Ty2 strain.Journal of microbiology (Seoul, Korea) · 2017Article
- Potential role of autophagy in the bactericidal activity of human PMNs for Bacillus anthracis.Pathogens and disease · 2015Article
- The Exosporium Layer of Bacterial Spores: a Connection to the Environment and the Infected Host.Microbiology and molecular biology reviews : MMBR · 2015Review
- Involvement of a 1-Cys peroxiredoxin in bacterial virulence.PLoS pathogens · 2014Article
- Transcriptomic and phenotypic analysis of paralogous spx gene function in Bacillus anthracis Sterne.MicrobiologyOpen · 2013Article
- Unveiling the novel dual specificity protein kinases in Bacillus anthracis: identification of the first prokaryotic dual specificity tyrosine phosphorylation-regulated kinase (DYRK)-like kinase.The Journal of biological chemistry · 2012Article
- Membrane topology of the Bacillus anthracis GerH germinant receptor proteins.Journal of bacteriology · 2012Article
- Cellular iron distribution in Bacillus anthracis.Journal of bacteriology · 2012Article
- Strand-specific RNA-seq reveals ordered patterns of sense and antisense transcription in Bacillus anthracis.PloS one · 2012Article
- Regulation of petrobactin and bacillibactin biosynthesis in Bacillus anthracis under iron and oxygen variation.PloS one · 2011Article
- Article
- Genetic analysis of petrobactin transport in Bacillus anthracis.Molecular microbiology · 2010Article
- Novel and unique diagnostic biomarkers for Bacillus anthracis infection.Applied and environmental microbiology · 2009Article
- Four superoxide dismutases contribute to Bacillus anthracis virulence and provide spores with redundant protection from oxidative stress.Infection and immunity · 2009Article
- Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Bacillus anthracis chromosome encodes four unique, putative superoxide dismutase (sod) genes. During exponential growth and sporulation, sodA1, sodA2, and sodC are transcribed constitutively throughout the growth cycle as individual genes. In contrast, the transcription of sod15 occurs mainly during late exponential and sporulation phases as part of a four-gene operon that may be involved in spore formation. Vegetative cell and spore lysates of wild-type Sterne and superoxide dismutase deletion (Deltasod) mutants show detectable SOD activity for SODA1 and SODA2, and protein analysis suggests that these two proteins form active homodimers and heterodimers. A comparison of the growth of parental versus Deltasod mutants under various chemical oxidative stresses indicates that DeltasodA1 mutants are particularly sensitive to endogenously produced superoxide, whereas DeltasodA2, Deltasod15, and DeltasodC mutants remain as resistant to this stress as the parental strain. In addition, in mouse survival assays, Deltasod15 and DeltasodA1 were responsible for less end-point death, but the level of decreased virulence does not fall within a statistically significant range. Collectively, these data show that sodA1 acts as a major protectant from intracellular superoxide stress, that sod15 is transcribed as part of an operon that may play a role in cell morphology, and that sodA2 and sodC may have minor roles that are not apparent in the conditions tested here.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.