ArticleJournal of bacteriology2006
Functional analysis of glucan binding protein B from Streptococcus mutans.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Characterization of MreCD inJournal of oral microbiology · 2025Article
- In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe.Journal of the American Chemical Society · 2024Article
- Anti-bacterial and anti-biofilm activities of arachidonic acid against the cariogenic bacteriumFrontiers in microbiology · 2024Article
- Streptococcus mutans requires mature rhamnose-glucose polysaccharides for proper pathophysiology, morphogenesis and cellular division.Molecular microbiology · 2019Article
- PcsB Expression Diversity Influences onFrontiers in microbiology · 2019Article
- Activity of Streptococcus mutans VicR Is Modulated by Antisense RNA.Journal of dental research · 2018Article
- Mutans Streptococci counts from saliva and its protein profile in early childhood caries.Interventional medicine & applied science · 2018Article
- The two-component system VicRK regulates functions associated with Streptococcus mutans resistance to complement immunity.Molecular oral microbiology · 2017Article
- Two-component signal transduction systems in oral bacteria.Journal of oral microbiology · 2017Review
- Triethylene Glycol Up-Regulates Virulence-Associated Genes and Proteins in Streptococcus mutans.PloS one · 2016Article
- A new small molecule inhibits Streptococcus mutans biofilms in vitro and in vivo.Journal of applied microbiology · 2015Article
- The copYAZ Operon Functions in Copper Efflux, Biofilm Formation, Genetic Transformation, and Stress Tolerance in Streptococcus mutans.Journal of bacteriology · 2015Article
- The anti-adhesive mode of action of a purified mushroom (Lentinus edodes) extract with anticaries and antigingivitis properties in two oral bacterial phatogens.BMC complementary and alternative medicine · 2014Article
- Differences in virulence of pneumolysin and autolysin mutants constructed by insertion duplication mutagenesis and in-frame deletion in Streptococcus pneumoniae.BMC biotechnology · 2014Article
- Article
- Microbial interactions in building of communities.Molecular oral microbiology · 2013Review
- Article
- Regulation of bacteriocin production and cell death by the VicRK signaling system in Streptococcus mutans.Journal of bacteriology · 2012Article
- Complete genome and transcriptomes of Streptococcus parasanguinis FW213: phylogenic relations and potential virulence mechanisms.PloS one · 2012Article
- Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Mutans streptococci are major etiological agents of dental caries, and several of their secreted products contribute to bacterial accumulation on teeth. Of these, Streptococcus mutans glucan binding protein B (GbpB) is a novel, immunologically dominant protein. Its biological function is unclear, although GbpB shares homology with a putative peptidoglycan hydrolase from S. agalactiae and S. pneumoniae, indicative of a role in murein biosynthesis. To determine the cellular function of GbpB, we used several approaches to inactivate the gene, analyze its expression, and identify interacting proteins. None of the transformants analyzed were true gbpB mutants, since they all contained both disrupted and wild-type gene copies, and expression of functional GbpB was always conserved. Thus, the inability to obtain viable gbpB null mutants supports the notion that gbpB is an essential gene. Northern blot and real-time PCR analyses suggested that induction of gbpB expression in response to stress was a strain-dependent phenomenon. Proteins that interacted with GbpB were identified in pull-down and coimmunoprecipitation assays, and these data suggest that GbpB interacts with ribosomal protein L7/L12, possibly as part of a protein complex involved in peptidoglycan synthesis and cell division.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.