ArticleNucleic acids research2006
Multiple start codons and phosphorylation result in discrete Rad52 protein species.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- A large C-terminal Rad52 segment acts as a chaperone to Form and Stabilize Rad51 Filaments.Nature communications · 2025Article
- Characterization of theGenes · 2023Article
- S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive.PLoS genetics · 2022Article
- Article
- Emerging non-canonical roles for the Rad51-Rad52 interaction in response to double-strand breaks in yeast.Current genetics · 2020Review
- Differential RPA-1 and RAD-51 recruitment in vivo throughout the C. elegans germline, as revealed by laser microirradiation.Nucleic acids research · 2018Article
- Review
- SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination.DNA repair · 2016Article
- Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules.Nature structural & molecular biology · 2014Article
- Article
- Rad52 sumoylation prevents the toxicity of unproductive Rad51 filaments independently of the anti-recombinase Srs2.PLoS genetics · 2013Article
- Homologous recombination and its regulation.Nucleic acids research · 2012Review
- Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding.The EMBO journal · 2011Article
- Vital roles of the second DNA-binding site of Rad52 protein in yeast homologous recombination.The Journal of biological chemistry · 2011Article
- Srs2: the "Odd-Job Man" in DNA repair.DNA repair · 2010Review
- Timing is everything: cell cycle control of Rad52.Cell division · 2010Article
- Regulation of homologous recombination in eukaryotes.Annual review of genetics · 2010Review
- Two Dot1 isoforms in Saccharomyces cerevisiae as a result of leaky scanning by the ribosome.Nucleic acids research · 2009Article
- Rad52 recruitment is DNA replication independent and regulated by Cdc28 and the Mec1 kinase.The EMBO journal · 2009Article
- Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
The sequence of the Saccharomyces cerevisiae RAD52 gene contains five potential translation start sites and protein-blot analysis typically detects multiple Rad52 species with different electrophoretic mobilities. Here we define the gene products encoded by RAD52. We show that the multiple Rad52 protein species are due to promiscuous choice of start codons as well as post-translational modification. Specifically, Rad52 is phosphorylated both in a cell cycle-independent and in a cell cycle-dependent manner. Furthermore, phosphorylation is dependent on the presence of the Rad52 C terminus, but not dependent on its interaction with Rad51. We also show that the Rad52 protein can be translated from the last three start sites and expression from any one of them is sufficient for spontaneous recombination and the repair of gamma-ray-induced double-strand breaks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.