ArticleProceedings of the National Academy of Sciences of the United States of America2006
Evolution of hepatitis C viral quasispecies and hepatic injury in perinatally infected children followed prospectively.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- [Prevention and factors associated with anti-HCV carriage in pregnant women living in Cotonou].The Pan African medical journal · 2020Article
- High-Resolution Evolutionary Analysis of Within-Host Hepatitis C Virus Infection.The Journal of infectious diseases · 2019Article
- Hepacivirus A Infection in Horses Defines Distinct Envelope Hypervariable Regions and Elucidates Potential Roles of Viral Strain and Adaptive Immune Status in Determining Envelope Diversity and Infection Outcome.Journal of virology · 2018Article
- Vertical Transmission of Hepatitis C Virus: Variable Transmission Bottleneck and Evidence of MidgestationJournal of virology · 2017Article
- Phylogenetic Diversity in Core Region of Hepatitis C Virus Genotype 1a as a Factor Associated with Fibrosis Severity in HIV-1-Coinfected Patients.BioMed research international · 2017Article
- Exceptional Heterogeneity in Viral Evolutionary Dynamics Characterises Chronic Hepatitis C Virus Infection.PLoS pathogens · 2016Article
- Evidence for deleterious hepatitis C virus quasispecies mutation loads that differentiate the response patterns in IFN-based antiviral therapy.The Journal of general virology · 2016Article
- Review
- Vertical transmission of hepatitis C virus: Current knowledge and perspectives.World journal of hepatology · 2014Review
- Evidence of distinct populations of hepatitis C virus in the liver and plasma of patients co-infected with HIV and HCV.Journal of medical virology · 2014Article
- To treat or not to treat the "immunotolerant phase" of hepatitis B infection: A tunnel of controversy.World journal of hepatology · 2014Review
- Vertical transmission of hepatitis C virus: a tale of multiple outcomes.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Review
- Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors.European journal of medicinal chemistry · 2012Article
- Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission.Journal of clinical microbiology · 2012Article
- A new evolutionary model for hepatitis C virus chronic infection.PLoS pathogens · 2012Article
- Hepatitis C virus antigenic convergence.Scientific reports · 2012Article
- Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively.The Journal of infectious diseases · 2011Article
- Complexity and catalytic efficiency of hepatitis C virus (HCV) NS3 and NS4A protease quasispecies influence responsiveness to treatment with pegylated interferon plus ribavirin in HCV/HIV-coinfected patients.Journal of virology · 2011Article
- Hepatitis C virus quasispecies in chronically infected children subjected to interferon-ribavirin therapy.Archives of virology · 2010Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Perinatal infection with hepatitis C virus (HCV) is characterized by a wide range of alanine aminotransferase (ALT) levels. The mechanisms responsible for this variability are unknown. We examined whether the evolution of the HCV quasispecies was associated with different ALT profiles in perinatally infected children. Sequences within HCV envelope 1 and 2 genes, inclusive of the hypervariable region 1, the viral load, and the nascent humoral immunity were analyzed in serial serum samples from 12 perinatally infected children prospectively followed for a median of 53 months. These patients were selected to represent two different ALT patterns during the first year of life: 6 had high levels (maximum values ranging from 4.2 to 30 times the normal upper limit), and 6 had normal or slightly elevated levels (< 2 times the normal upper limit). Two patterns of viral evolution were identified according to the ALT profiles. Biochemical evidence of hepatic injury was invariably associated with a mono- or oligoclonal viral population, whereas mild or no liver damage correlated with the early emergence of a heterogeneous viral quasispecies. Consistent with selective immune pressure, amino acid changes occurred almost exclusively within the hypervariable region 1 and were temporally associated with antibody seroconversion; at this time, the difference in genetic diversity between the two groups was highly significant (P = 0.002). The two patterns of viral evolution persisted over time and did not correlate with viral load or genotype. Our study demonstrates that, in perinatally infected children, the evolution of HCV quasispecies correlates with hepatic injury. The sequences reported in this paper have been deposited in the GenBank database (accession nos. DQ 504441-DQ 507112).
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