ArticleBMC genomics2006
angaGEDUCI: Anopheles gambiae gene expression database with integrated comparative algorithms for identifying conserved DNA motifs in promoter sequences.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Evolution of gene expression levels in the male reproductive organs ofLife science alliance · 2019Article
- Redox state affects fecundity and insecticide susceptibility in Anopheles gambiae.Scientific reports · 2018Article
- Identification of immunity-related genes in Plutella xylostella in response to fungal peptide destruxin A: RNA-Seq and DGE analysis.Scientific reports · 2017Article
- The impact of metagenomic interplay on the mosquito redox homeostasis.Free radical biology & medicine · 2017Review
- The Entomopathogenic FungiFrontiers in microbiology · 2017Article
- Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The roles of serpins in mosquito immunology and physiology.Journal of insect physiology · 2013Review
- Biochemical characterization of Anopheles gambiae SRPN6, a malaria parasite invasion marker in mosquitoes.PloS one · 2012Article
- Ookinete-interacting proteins on the microvillar surface are partitioned into detergent resistant membranes of Anopheles gambiae midguts.Journal of proteome research · 2011Article
- aeGEPUCI: a database of gene expression in the dengue vector mosquito, Aedes aegypti.BMC research notes · 2010Article
- Silencing of carbonic anhydrase in an Anopheles gambiae larval cell line, Ag55.Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research · 2009Article
- Comparative genomics allows the discovery of cis-regulatory elements in mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: potential tools for control of female feeding and reproduction.Insect biochemistry and molecular biology · 2008Article
- Gene expression studies in mosquitoes.Advances in genetics · 2008Review
Corrections and comments
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Authors and funding
4 authors.
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Abstract
backgroundThe completed sequence of the Anopheles gambiae genome has enabled genome-wide analyses of gene expression and regulation in this principal vector of human malaria. These investigations have created a demand for efficient methods of cataloguing and analyzing the large quantities of data that have been produced. The organization of genome-wide data into one unified database makes possible the efficient identification of spatial and temporal patterns of gene expression, and by pairing these findings with comparative algorithms, may offer a tool to gain insight into the molecular mechanisms that regulate these expression patterns. DESCRIPTION: We provide a publicly-accessible database and integrated data-mining tool, angaGEDUCI, that unifies 1) stage- and tissue-specific microarray analyses of gene expression in An. gambiae at different developmental stages and temporal separations following a bloodmeal, 2) functional gene annotation, 3) genomic sequence data, and 4) promoter sequence comparison algorithms. The database can be used to study genes expressed in particular stages, tissues, and patterns of interest, and to identify conserved promoter sequence motifs that may play a role in the regulation of such expression. The database is accessible from the address http://www.angaged.bio.uci.edu.
conclusionBy combining gene expression, function, and sequence data with integrated sequence comparison algorithms, angaGEDUCI streamlines spatial and temporal pattern-finding and produces a straightforward means of developing predictions and designing experiments to assess how gene expression may be controlled at the molecular level.
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