ArticleTheoretical biology & medical modelling2006
Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data.
Article in Theoretical biology & medical modelling, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Subcritical Sevastyanov branching processes with nonhomogeneous Poisson immigration.Journal of applied probability · 2017Article
- Somatic mosaicism: implications for disease and transmission genetics.Trends in genetics : TIG · 2015Review
- Asymptotic behavior of cell populations described by two-type reducible age-dependent branching processes with non-homogeneous immigration().Mathematical population studies · 2012Article
- Quasi- and pseudo-maximum likelihood estimators for discretely observed continuous-time Markov branching processes.Journal of statistical planning and inference · 2011Article
- A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process.Biostatistics (Oxford, England) · 2011Article
- Two-Type Age-Dependent Branching Processes with Inhomogeneous Immigration as Models of Renewing Cell Populations.Pliska. Pliiska · 2011Article
- Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors.Cancer research · 2010Article
- An age-dependent branching process model for the analysis of CFSE-labeling experiments.Biology direct · 2010Article
- Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications.Biometrics · 2010Article
- On the impact of correlation between collaterally consanguineous cells on lymphocyte population dynamics.Journal of mathematical biology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe purpose of this paper is two-fold. The first objective is to validate the assumptions behind a stochastic model developed earlier by these authors to describe oligodendrocyte generation in cell culture. The second is to generate time-lapse data that may help biomathematicians to build stochastic models of cell proliferation and differentiation under other experimental scenarios.
resultsUsing time-lapse video recording it is possible to follow the individual evolutions of different cells within each clone. This experimental technique is very laborious and cannot replace model-based quantitative inference from clonal data. However, it is unrivalled in validating the structure of a stochastic model intended to describe cell proliferation and differentiation at the clonal level. In this paper, such data are reported and analyzed for oligodendrocyte precursor cells cultured in vitro.
conclusionThe results strongly support the validity of the most basic assumptions underpinning the previously proposed model of oligodendrocyte development in cell culture. However, there are some discrepancies; the most important is that the contribution of progenitor cell death to cell kinetics in this experimental system has been underestimated.
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