Evidence map›Paper›PMID 16705795›Full record

ArticleInternational journal of environmental research and public health2005

Systems biology: new approaches to old environmental health problems.

William A Toscano, Kristen P Oehlke

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies.Journal of experimental zoology. Part A, Comparative experimental biology · 2006
    Review
  9. The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks.Toxicological sciences : an official journal of the Society of Toxicology · 2006
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

William A ToscanoDiv. of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA. tosca001@umn.edu
Kristen P Oehlke
Minnesota Department of Health · USUniversity of Minnesota · US

Funding

NRSA Training Grant in Environmental &Occupational Hea*T32ES010956 · NIEHS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TOSCANO, WILLIAM A · 2001 to 2006
$448k
A systems biology approach to hormone active agentsR13ES013379 · NIEHS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TOSCANO, WILLIAM A · 2004 to 2004
$5k
NIEHS NIH HHS ES-013379NIEHS NIH HHS ES-10956NIEHS NIH HHS R13 ES013379NIEHS NIH HHS T32 ES010956
6 · The paper itself

Abstract

The environment plays a pivotal role as a human health determinant and presence of hazardous pollutants in the environment is often implicated in human disease. That pollutants cause human diseases however is often controversial because data connecting exposure to environmental hazards and human diseases are not well defined, except for some cancers and syndromes such as asthma. Understanding the complex nature of human-environment interactions and the role they play in determining the state of human health is one of the more compelling problems in public health. We are becoming more aware that the reductionist approach promulgated by current methods has not, and will not yield answers to the broad questions of population health risk analysis. If substantive applications of environment-gene interactions are to be made, it is important to move to a systems level approach, to take advantage of epidemiology and molecular genomic advances. Systems biology is the integration of genomics, transcriptomics, proteomics, and metabolomics together with computer technology approaches to elucidate environmentally caused disease in humans. We discuss the applications of environmental systems biology as a route to solution of environmental health problems.

Indexed as

Environmental HealthSystems BiologyEnvironmental ExposureGenomicsHumans

Identifiers

PMID16705795
PMCPMC3814690
OpenAlexW2163053177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.