ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2006
Fever in patients with mixed-species malaria.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 24 citations in OpenAlex.
- Co-infection of the four major Plasmodium species: Effects on densities and gametocyte carriage.PLoS neglected tropical diseases · 2022Article
- The Consequences of Mixed-Species Malaria Parasite Co-Infections in Mice and Mosquitoes for Disease Severity, Parasite Fitness, and Transmission Success.Frontiers in immunology · 2019Article
- Manifestation of malaria in Mangaluru, southern India.Malaria journal · 2018Article
- Joint Modeling of MixedThe American journal of tropical medicine and hygiene · 2018Article
- Frequency and distribution of mixed Plasmodium falciparum-vivax infections in French Guiana between 2000 and 2008.Malaria journal · 2015Article
- Article
- Parasite virulence, co-infections and cytokine balance in malaria.Pathogens and global health · 2014Review
- Cytokine balance in human malaria: does Plasmodium vivax elicit more inflammatory responses than Plasmodium falciparum?PloS one · 2012Article
- Plasmodium knowlesi Malaria in humans and macaques, Thailand.Emerging infectious diseases · 2011Article
- Immune response to Plasmodium vivax has a potential to reduce malaria severity.Clinical and experimental immunology · 2010Article
- Gametocytemia and fever in human malaria infections.The Journal of parasitology · 2007Article
- Gametocytemia in Plasmodium vivax and Plasmodium falciparum infections.The Journal of parasitology · 2006Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundClinical symptoms of mixed-species malaria infections have been variously reported as both less severe and more severe than those of single-species infections.
methodsOral temperatures were taken from and blood slides were prepared for 2308 adults who presented at outpatient malaria clinics in Tak Province (Thailand) during May-August 1998, May-July 1999, and May-June 2001 with malaria infections diagnosed by 2 expert research microscopists, each of whom was blinded to the other's reports.
resultsIn each year, temperatures of patients with mixed Plasmodium vivax-Plasmodium falciparum infections were higher than temperatures of patients with P. vivax or P. falciparum infections. In every mixed-species case, P. falciparum parasitemia was higher than P. vivax parasitemia, but patient temperature was not correlated with the parasitemia of either species or with the total parasitemia.
conclusionsAmong adults who self-report to malaria clinics in western Thailand, patients with mixed P. vivax-P. falciparum infections have higher fevers than patients with single-species infections, a distinction that cannot be attributed to differences in parasitemia. This observation warrants more detailed investigations, spanning wider ranges of ages and transmission environments.
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