ArticleMolecular and cellular biology2006
The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops.Nucleic acids research · 2022Article
- Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Immunoinformatics approach for multi-epitope vaccine design against structural proteins and ORF1a polyprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).Tropical diseases, travel medicine and vaccines · 2021Article
- E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells.Genes & development · 2013Article
- Simultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathways.PloS one · 2013Article
- Identification of core DNA elements that target somatic hypermutation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Requirement of upstream Hfq-binding (ARN)x elements in glmS and the Hfq C-terminal region for GlmS upregulation by sRNAs GlmZ and GlmY.Nucleic acids research · 2012Article
- Three-dimensional architecture of the IgH locus facilitates class switch recombination.Annals of the New York Academy of Sciences · 2012Article
- AID targeting is dependent on RNA polymerase II pausing.Seminars in immunology · 2012Review
- Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.Advances in cancer research · 2012Review
- Epigenetic reprogramming: is deamination key to active DNA demethylation?Reproduction (Cambridge, England) · 2011Review
- AID: a riddle wrapped in a mystery inside an enigma.Immunologic research · 2011Review
- Article
- AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.PLoS genetics · 2011Article
- Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- A coming-of-age story: activation-induced cytidine deaminase turns 10.Nature immunology · 2009Review
- Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.Biochemical Society transactions · 2009Article
- V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Activation-induced cytidine deaminase (AID) is a single-stranded DNA deaminase required for somatic hypermutation of immunoglobulin (Ig) genes, a key process in the development of adaptive immunity. Transcription provides a single-stranded DNA substrate for AID, both in vivo and in vitro. We present here an assay which can faithfully replicate all of the molecular features of the initiation of hypermutation of Ig genes in vivo. In this assay, which detects AID-mediated deamination in the context of transcription by Escherichia coli RNA polymerase, deamination targets either strand and declines in efficiency as the distance from the promoter increases. We show that AID binds DNA exposed by the transcribing polymerase, implicating the polymerase itself as the vehicle which distributes AID on DNA as it moves away from the promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.