SynthesisEmerging infectious diseases2006
Isoniazid preventive therapy and risk for resistant tuberculosis.
Synthesis in Emerging infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
108 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Effectiveness of interventions for reducing TB incidence in countries with low TB incidence: a systematic review of reviews.European respiratory review : an official journal of the European Respiratory Society · 2019Pooled it
- Child contact management in high tuberculosis burden countries: A mixed-methods systematic review.PloS one · 2017Pooled it
- Rifampicin resistance after treatment for latent tuberculous infection: a systematic review and meta-analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2016Pooled it
- Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB.The Cochrane database of systematic reviews · 2013Pooled it
- Pooled it
- Pooled it
- Effect of pre-medication on early adverse reactions following antivenom use in snakebite: a systematic review and meta-analysis.Drug safety · 2011Pooled it
- Tuberculosis (HIV-negative people).BMJ clinical evidence · 2011Pooled it
- Treatment of latent tuberculosis infection in HIV infected persons.The Cochrane database of systematic reviews · 2010Pooled it
- Tuberculosis (HIV-negative people).BMJ clinical evidence · 2009Pooled it
- Rapid molecular testing or chest X-ray or tuberculin skin testing for household contact assessment of tuberculosis infection: A cluster-randomized trial.PLoS medicine · 2025Trial
- Trial
- New regimens to prevent tuberculosis in adults with HIV infection.The New England journal of medicine · 2011Trial
- Integrated HIV and TB Services for the Management of Coinfection in West Africa: A Scoping Review of Strategies, Outcomes, Barriers and Enablers.Health science reports · 2026Review
- Embracing Tuberculosis Preventive Treatment: A Crucial Step towards TB Control in Pakistan.Pakistan journal of medical sciences · 2026Article
- Breakthrough Tuberculosis in a Large Cohort of People Living With HIV on Preventive Treatment.Tropical medicine & international health : TM & IH · 2026Article
- Reply to the letter on "Brazilian guidelines for the management of tuberculosis infection in immune-mediated inflammatory diseases: is retesting in latent tuberculosis screening appropriate and safe?"Advances in rheumatology (London, England) · 2025Article
- Between Process Gaps, Knowledge, and Patient Trust: Healthcare Workers' Insights on Implementing Tuberculosis Preventive Therapy for People with HIV in the Philippines and Indonesia.Implementation science communications · 2025Article
- Lower Tuberculosis Incidence Among People With HIV Who Completed Isoniazid Preventive Therapy in Ukraine, a High-Burden Multidrug-Resistant Tuberculosis Setting: A Retrospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Integrating Early Tuberculosis States Into Contact Management in Peru.JAMA network open · 2025Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the context of tuberculosis (TB) resurgence, isoniazid preventive therapy (IPT) is increasingly promoted, but concerns about the risk for development of isoniazid-resistant tuberculosis may hinder its widespread implementation. We conducted a systematic review of data published since 1951 to assess the effect of primary IPT on the risk for isoniazid-resistant TB. Different definitions of isoniazid resistance were used, which affected summary effect estimates; we report the most consistent results. When all 13 studies (N = 18,095 persons in isoniazid groups and N = 17,985 persons in control groups) were combined, the summary relative risk for resistance was 1.45 (95% confidence interval 0.85-2.47). Results were similar when studies of HIV-uninfected and HIV-infected persons were considered separately. Analyses were limited by small numbers and incomplete testing of isolates, but findings do not exclude an increased risk for isoniazid-resistant TB after IPT. The diagnosis of active TB should be excluded before IPT. Continued surveillance for isoniazid resistance is essential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.