ArticleEmerging infectious diseases2006
Identifying and quantifying genotypes in polyclonal infections due to single species.
Article in Emerging infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Molecular incidence and clearance of Plasmodium falciparum infection.Malaria journal · 2015Article
- Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria.Journal of immunology research · 2015Article
- Article
- Improving malaria control in West Africa: interruption of transmission as a paradigm shift.Acta tropica · 2012Article
- Human cerebral malaria and Plasmodium falciparum genotypes in Malawi.Malaria journal · 2012Article
- Chloroquine-resistant haplotype Plasmodium falciparum parasites, Haiti.Emerging infectious diseases · 2009Article
- Effects of Plasmodium falciparum mixed infections on in vitro antimalarial drug tests and genotyping.The American journal of tropical medicine and hygiene · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Simultaneous infection with multiple pathogens of the same species occurs with HIV, hepatitis C, Epstein-Barr virus, dengue, tuberculosis, and malaria. However, available methods do not distinguish among or quantify pathogen genotypes in individual patients; they also cannot test for novel insertions and deletions in genetically modified organisms. The strategy reported here accomplishes these goals with real-time polymerase chain reaction (PCR) and capillary electrophoresis. Real-time PCR with allotype-specific primers defines the allotypes (strains) present and the intensity of infection (copy number). Capillary electrophoresis defines the number of genotypes within each allotype and the intensity of infection by genotype. This strategy can be used to study the epidemiology of emerging infectious diseases with simultaneous infection by multiple genotypes, as demonstrated here with malaria. It also permits testing for insertions or deletions in genetically modified organisms that may be used for bioterrorism.
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Registered trials
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