ArticleEmerging infectious diseases2006
Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003.
Article in Emerging infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 259 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fecal Microbiota Transplantation Versus Standard Medical Therapy for Initial Treatment of Recurrent Clostridium Difficile Infection
Phase III,randomized,double-blinded Clinical Trial to Evaluate the Effectiveness and Safety of Oral Vancomycin Vs Placebo in the Prevention of Recurrence of C.difficile Infection in Patients Under Treatment with Systemic Antibiotic Therapy
Who cites it
259 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Clostridioides difficile Infection in Patients with Chronic Kidney Disease: A Systematic Review.BioMed research international · 2021Pooled it
- Global burden ofJournal of global health · 2019Pooled it
- Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis.Canadian journal of gastroenterology & hepatology · 2016Pooled it
- Chronic kidney disease and end-stage renal disease are risk factors for poor outcomes of Clostridium difficile infection: a systematic review and meta-analysis.International journal of clinical practice · 2015Pooled it
- The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Pooled it
- Evaluation of the effectiveness and safety of oral vancomycin versus placebo in the prevention of recurrence ofBMJ open · 2023Trial
- Impact of Surotomycin on the Gut Microbiota of Healthy Volunteers in a Phase 1 Clinical Trial.Antimicrobial agents and chemotherapy · 2016Trial
- Decreased cure and increased recurrence rates for Clostridium difficile infection caused by the epidemic C. difficile BI strain.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Trial
- Randomized double-blind clinical trial evaluating the effectiveness and safety of secondary prophylaxis with oral vancomycin versus placebo in the prevention of recurrence ofJAC-antimicrobial resistance · 2026Article
- Global burden and trends of theAnnals of medicine · 2025Observational
- History and Evolution of the HypervirulentMicroorganisms · 2025Review
- Prevention and treatment of antibiotics-associated adverse effects through the use of probiotics: A review.Journal of advanced research · 2025Review
- Synthesis of PSI Oligosaccharide for the Development of Total Synthetic Vaccine againstThe Journal of organic chemistry · 2025Article
- Novel phenylthiazoles with aRSC advances · 2024Article
- Probiotics: insights and new opportunities forCritical reviews in microbiology · 2023Review
- Evidence of within-facility patient-patientEpidemiology and infection · 2022Article
- Clostridium difficile infection after ileostomy closure and anastomotic failure in rectal cancer surgery patients.BJS open · 2022Article
- Family Stool Donation Predicts Failure of Fecal Microbiota Transplant forGastro hep advances · 2022Article
199 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
US hospital discharges for which Clostridium difficile-associated disease (CDAD) was listed as any diagnosis doubled from 82,000 (95% confidence interval [CI] 71,000-94,000) or 31/100,000 population in 1996 to 178,000 (95% CI 151,000-205,000) or 61/100,000 in 2003; this increase was significant between 2000 and 2003 (slope of linear trend 9.48; 95% CI 6.16-12.80, p = 0.01). The overall rate during this period was severalfold higher in persons >65 years of age (228/100,000) than in the age group with the next highest rate, 45-64 years (40/100,000; p < or = 0.001). CDAD appears to be increasing rapidly in the United States and is disproportionately affecting older persons. Clinicians should be aware of the increasing risk for CDAD and make efforts to control transmission of C. difficile and prevent disease.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.