Evidence map›Paper›PMID 16703577›Full record

ArticlePediatric pulmonology2006

Association of birth weight with asthma-related outcomes at age 2 years.

Elsie M Taveras, Carlos A Camargo, Sheryl L Rifas-Shiman, Emily Oken, Diane R Gold, Scott T Weiss, Matthew W Gillman

Open access · greenAbstract read
In one paragraph

Article in Pediatric pulmonology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Is there a link between wheezing in early childhood and adverse birth outcomes? A systematic review.International journal of environmental research and public health · 2009
    Pooled it
  5. Trial
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Influence of childhood growth on asthma and lung function in adolescence.The Journal of allergy and clinical immunology · 2015
    Article
  11. Cohort profile: project viva.International journal of epidemiology · 2015
    Observational
  12. Birth weight and asthma incidence by asthma phenotype pattern in a racially diverse cohort followed through adolescence.The Journal of asthma : official journal of the Association for the Care of Asthma · 2015
    Article
  13. Review
  14. Birth weight, gestational age, fetal growth and childhood asthma hospitalization.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2014
    Article
  15. Article
  16. Evaluation of risk factors for recurrent wheezing episodes.Journal of clinical medicine research · 2013
    Article
  17. Population-based study on association between birth weight and risk of asthma: a propensity score approach.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013
    Article
  18. Fetal growth and risk of childhood asthma and allergic disease.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elsie M TaverasDepartment of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA. Elsie.Taveras@childrens.harvard.edu
Carlos A Camargo
Sheryl L Rifas-Shiman
Emily Oken
Diane R Gold
Scott T Weiss
Matthew W Gillman
Harvard University · USBrigham and Women's Hospital · USHarvard Pilgrim Health Care · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Alessio Fasano · 1994 to 2026
$31.6M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
NUTRITION IN PREGNANCY, BIRTH WEIGHT, &CHILDHOOD ASTHMAR01HL064925 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2000 to 2010
$7.5M
Pre- and Peri-natal Predictors of Childhood ObesityR37HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2012 to 2015
$4.5M
Patient-oriented research in early life origins of CVDK24HL068041 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2001 to 2010
$1.4M
NHLBI NIH HHS HL 64925NHLBI NIH HHS HL 68041NHLBI NIH HHS K24 HL068041NHLBI NIH HHS R01 HL064925NICHD NIH HHS HD 34568NICHD NIH HHS R01 HD034568NICHD NIH HHS R37 HD034568NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

backgroundAlthough lower birth weight associated with prematurity raises the risk of asthma in childhood, few prospective studies have examined higher birth weight, and few have separated the two components of birth weight, fetal growth and length of gestation.

objectiveTo examine the associations of fetal growth and length of gestation with asthma-related outcomes by age 2 years.

methodsWe studied 1,372 infants and toddlers born after 34 weeks' gestation in Project Viva, a prospective cohort study of pregnant mothers and their children. The main outcome measures were parent report of (1) any wheezing (or whistling in the chest) from birth to age 2 years, (2) recurrent wheezing during the first 2 years of life, and (3) doctor's diagnosis of asthma, wheeze or reactive airway disease ("asthma") by age 2. We calculated gestational age from the last menstrual period or ultrasound examination, and determined birth weight for gestational age z-value ("fetal growth") using US national reference data.

resultsInfants' mean birth weight was 3,527 (SD, 517; range, 1,559-5,528) grams. By age 2 years, 34% of children had any wheezing, 14% had recurrent wheezing, and 16% had doctor-diagnosed asthma. After adjusting for several parent, child, and household characteristics in logistic regression models, we found that infants with birth weight > or = 4,000 g were not more likely to have any wheezing (odds ratio (OR), 0.91; 95% confidence interval (CI): 0.62, 1.34) or doctor-diagnosed asthma (OR, 0.80; 95% CI: 0.49, 1.31) than infants with birth weight 3,500-3,999 g. In models examining length of gestation and fetal growth separately, neither the highest nor the lowest groups of either predictor were associated with the three outcomes. Boys had a higher incidence of asthma-related outcomes than girls, and exposure to passive smoking, parental history of asthma, and exposure to older siblings were all associated with greater risk of recurrent wheeze or asthma-related outcomes at age 2 years.

conclusionAlthough male sex, exposure to smoking, parental history of asthma, and exposure to older siblings were associated with increased risk of wheezing and asthma-related outcomes in this prospective study of children born after 34 weeks gestation, fetal growth and length of gestation were not.

Indexed as

Birth WeightFetal DevelopmentAdolescentAdultAsthmaChild, PreschoolFemaleGestational AgeHumansMaleProspective Studies

Identifiers

PMID16703577
PMCPMC1488724
OpenAlexW2062925423

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.