ArticlePsychopharmacology2006
Dopamine D4 receptor polymorphism modulates cue-elicited heroin craving in Chinese.
Article in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention.BMC pediatrics · 2013Trial
- Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch.The pharmacogenomics journal · 2008Trial
- DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues.Psychopharmacology · 2007Trial
- Beyond Stigma-Integrating Neurobiology, Genetics, and Awareness Integration Theory in Addiction Recovery.Psychology research and behavior management · 2026Article
- Behavioural effects of APH199, a selective dopamine D4 receptor agonist, in animal models.Psychopharmacology · 2023Article
- Article
- Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review.Movement disorders clinical practice · 2021Review
- Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors.Nutrients · 2020Review
- Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine.Current neuropharmacology · 2020Review
- Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population.Noro psikiyatri arsivi · 2019Article
- Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone.Pharmacology, biochemistry, and behavior · 2019Article
- Fear Memory Recall Potentiates Opiate Reward Sensitivity through Dissociable Dopamine D1 versus D4 Receptor-Dependent Memory Mechanisms in the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A prospective, longitudinal study to evaluate the clinical utility of a predictive algorithm that detects risk of opioid use disorder.Journal of pain research · 2018Article
- Genome-Wide Association of Heroin Dependence in Han Chinese.PloS one · 2016Article
- A review of pharmacogenetic studies of substance-related disorders.Drug and alcohol dependence · 2015Review
- Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels.Molecular psychiatry · 2013Article
- Advances in genetic studies of substance abuse in China.Shanghai archives of psychiatry · 2013Review
- Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence.PloS one · 2013Article
- Genetics of dopamine receptors and drug addiction.Human genetics · 2012Review
- Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSubjective craving, which contributes to the continuation of drug use in active abuser and the occurrence of relapse in detoxified abusers, is considered to be a central phenomenon in addiction. Dopamine pathway has been implicated in the mechanism underlying the cue-elicited craving for a variety of addictive substances.
objectivesThe objective of this study was to test the hypothesis that heroin addicts carrying D4 dopamine receptor gene (DRD4) variable number tandem repeat (VNTR) long type allele would have higher craving after exposure to a heroin-related cue. MATERIALS AND
methodsCraving was induced by a series of exposure to neutral and heroin-related cue and were assessed in a cohort of Chinese heroin abusers (n=420) recruited from the Voluntary Drug Dependence Treatment Center at Shanghai.
resultsSignificantly stronger cue-elicited heroin craving was found in individuals carrying DRD4 VNTR long type allele than the non-carriers (F=31.040, p<0.001). As for baseline craving and mean change in craving responding to neutral stimuli, no significance was found (1.06+/-0.34 vs 1.07+/-0.36, F=0.067, p=0.797 and 0.42+/-0.34 vs 0.45+/-0.37, F=0.277, p=0.599, respectively).
conclusionsThe results of our study suggest that DRD4 VNTR polymorphism contributes to cue-elicited craving in heroin dependence, indicating DRD4 VNTR represents one of potential genetic risk factors for cue-induced craving.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.