ArticleBritish journal of pharmacology2006
Local regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats.
Article in British journal of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Article
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- Regulation of the microvascular circulation in the leg muscles, pancreas and small intestine in rats.SpringerPlus · 2015Article
- TRPA1 is essential for the vascular response to environmental cold exposure.Nature communications · 2014Article
- Chemosensory information processing between keratinocytes and trigeminal neurons.The Journal of biological chemistry · 2014Article
- Effects of some anesthetic agents on skin microcirculation evaluated by laser Doppler perfusion imaging in mice.BMC veterinary research · 2013Article
- Imaging of temperature dependent hemodynamics in the rat sciatic nerve by functional photoacoustic microscopy.Biomedical engineering online · 2013Article
- Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats.The journal of physiological sciences : JPS · 2013Article
- Impact of 10 sessions of whole body cryostimulation on cutaneous microcirculation measured by laser Doppler flowmetry.Journal of human kinetics · 2011Article
- Bretylium abolishes neurotransmitter release without necessarily abolishing the nerve terminal action potential in sympathetic terminals.British journal of pharmacology · 2008Article
- Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.British journal of pharmacology · 2007Article
- Excitatory P2-receptors at sympathetic axon terminals: role in temperature control of cutaneous blood flow.British journal of pharmacology · 2006Article
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. This study investigated a local effect of cooling on the plantar skin blood flow (PSBF) of tetrodotoxin-treated rats by laser-Doppler flowmetry. 2. When the air temperature around the left foot was locally cooled from 25 to 10 degrees C, the PSBF of the left foot decreased. 3. The response was inhibited by the alpha-adrenoceptor antagonist phentolamine, the alpha1-adrenoceptor antagonist bunazosin, the alpha2-adrenoceptor antagonist RS79948, and bretylium and guanethidine that inhibit noradrenaline release from sympathetic nerves. Adrenalectomy of the rats did not affect the cooling-induced response. 4. The P2 purinoceptor antagonists suramin and PPADS also significantly suppressed the cooling-induced reduction of PSBF. However, the inhibitory effect of PPADS on the cooling-induced response was abolished after the treatment with phentolamine. Intra-arterial injections of ATPgammaS, a stable P2 purinoceptor agonist, at 25 degrees C caused a transient decrease in PSBF in a dose-dependent manner, which was significantly inhibited by phentolamine and guanethidine. 5. These results suggest a novel mechanism for local cooling-induced reduction of skin blood flow in vivo; moderate cooling of the skin induces the release of ATP, which stimulates presynaptic P2 purinoceptors on sympathetic nerve terminals and facilitates the release of noradrenaline, thereby causing contractions of skin blood vessels via the activation of alpha1-and alpha2-adrenoceptors.
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