ArticleBritish journal of pharmacology2006
Moclobemide upregulated Bcl-2 expression and induced neural stem cell differentiation into serotoninergic neuron via extracellular-regulated kinase pathway.
Article in British journal of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Article
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- Neuroprotective effect of L-deprenyl on the expression level of the Mst1 gene and inhibition of apoptosis in rat-model spinal cord injury.Iranian journal of basic medical sciences · 2022Article
- Attenuation of Anxiety-Like Behavior byPharmaceuticals (Basel, Switzerland) · 2020Article
- Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1-Deficient Mice.Molecular neurobiology · 2019Article
- Nutritional Regulators of Bcl-xL in the Brain.Molecules (Basel, Switzerland) · 2018Review
- Neuroprotective effects of selegiline on rat neural stem cells treated with hydrogen peroxide.Biomedical reports · 2018Article
- Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Anti-inflammatory, antiapoptotic, and antioxidant activity of fluoxetine.Pharmacology research & perspectives · 2016Review
- Effects of Antidepressants on DSP4/CPT-Induced DNA Damage Response in Neuroblastoma SH-SY5Y Cells.Neurotoxicity research · 2015Article
- Serotonin receptor 6 mediates defective brain development in monoamine oxidase A-deficient mouse embryos.The Journal of biological chemistry · 2014Article
- Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice.Neurobiology of aging · 2014Article
- Effects of sevoflurane on self-renewal capacity and differentiation of cultured neural stem cells.Neurochemical research · 2013Article
- Paroxetine up-regulates neurogenesis in hippocampus-derived neural stem cell from fetal rats.Molecular and cellular biochemistry · 2013Article
- ''70th Birthday Professor Riederer'' induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (-)deprenyl: a way to a disease-modifying therapy?Journal of neural transmission (Vienna, Austria : 1996) · 2013Review
- Comparison of expression pattern of monoamine oxidase A with histopathologic subtypes and tumour grade of renal cell carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- Pigment epithelium-derived factor (PEDF) protects cortical neurons in vitro from oxidant injury by activation of extracellular signal-regulated kinase (ERK) 1/2 and induction of Bcl-2.Neuroscience research · 2012Article
- Monoamine oxidase a expression is vital for embryonic brain development by modulating developmental apoptosis.The Journal of biological chemistry · 2011Article
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Abstract
1. Moclobemide (MB) is an antidepressant drug that selectively and reversibly inhibits monoamine oxidase-A. Recent studies have revealed that antidepressant drugs possess the characters of potent growth-promoting factors for the development of neurogenesis and improve the survival rate of serotonin (5-hydroxytrytamine; 5-HT) neurons. However, whether MB comprises neuroprotection effects or modulates the proliferation of neural stem cells (NSCs) needs to be elucidated. 2. In this study, firstly, we used the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to demonstrate that 50 microM MB can increase the cell viability of NSCs. The result of real-time reverse transcription-polymerase chain reaction (RT-PCR) showed that the induction of MB can upregulate the gene expressions of Bcl-2 and Bcl-xL. By using caspases 8 and 3, ELISA and terminal dUTP nick-end labeling (TUNEL) assay, our data further confirmed that 50 microM MB-treated NSCs can prevent FasL-induced apoptosis. 3. The morphological findings also supported the evidence that MB can facilitate the dendritic development and increase the neurite expansion of NSCs. Moreover, we found that MB treatment increased the expression of Bcl-2 in NSCs through activating the extracellular-regulated kinase (ERK) phosphorylation. 4. By using the triple-staining immunofluorescent study, the percentages of serotonin- and MAP-2-positive cells in the day 7 culture of MB-treated NSCs were significantly increased (P<0.01). Furthermore, our data supported that MB treatment increased functional production of serotonin in NSCs via the modulation of ERK1/2. In sum, the study results support that MB can upregulate Bcl-2 expression and induce the differentiation of NSCs into serotoninergic neuron via ERK pathway.
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