Evidence map›Paper›PMID 16702560›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2006

Serial coalescent simulations suggest a weak genealogical relationship between Etruscans and modern Tuscans.

Elise M S Belle, Uma Ramakrishnan, Joanna L Mountain, Guido Barbujani

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  5. Article
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  9. Article
  10. The Etruscan timeline: a recent Anatolian connection.European journal of human genetics : EJHG · 2009
    Article
  11. Article
  12. Article
  13. Article
  14. DNA evidence for historic population size and past ecosystem impacts of gray whales.Proceedings of the National Academy of Sciences of the United States of America · 2007
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elise M S BelleDipartimento di Biologia, Università di Ferrara, Via Borsari, 46, 44100 Ferrara, Italy.
Uma Ramakrishnan
Joanna L Mountain
Guido Barbujani

Funding

VARIATIONS OF HUMAN DNA SEQUENCESP01GM028428 · NIGMS · STANFORD UNIVERSITY · PI CAVALLI-SFORZA, LUIGI L · 1985 to 2004
$6.8M
NIGMS NIH HHS GM028428NIGMS NIH HHS P01 GM028428
6 · The paper itself

Abstract

The Etruscans, the only preclassical European population that has been genetically characterized so far, share only two haplotypes with their modern geographic counterparts, the Tuscans, who, nonetheless, appear to be their closest relatives. We modeled 10 demographic scenarios spanning the last 2,500 years and tested by serial coalescent simulation whether any are consistent with the patterns of genetic diversity observed within and between the Etruscan and the modern Tuscan populations. Models in which the Etruscans are the direct ancestors of modern Tuscans appear compatible with the observed data only when they also include a very high mutation rate and an ancient founder effect. A better fit was obtained when the ancient and the modern samples were extracted from two independently evolving populations, connected by little migration. Simulated and observed parameters were also similar for a scenario in which the ancient samples came from a subset, e.g., a social elite, genetically differentiated from the bulk of the Etruscan population. In principle, these results may be biased by factors such as gross and systematic errors in the ancient DNA sequences and failure to sample suitable modern individuals. If neither proves to be the case, this study strongly suggests that either the mitochondrial mutation rate is much higher than currently believed or the Etruscans left very few modern mitochondrial descendants.

Indexed as

Evolution, MolecularBiological EvolutionDNA, MitochondrialFounder EffectGenetics, PopulationGenetic VariationHaplotypesHumansItalyLikelihood FunctionsMutationPhylogenyTime FactorsDNA, Mitochondrial

Identifiers

PMID16702560
PMCPMC1472421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.