Evidence map›Paper›PMID 16702439›Full record

ArticleGenetics2006

Inferring population parameters from single-feature polymorphism data.

Rong Jiang, Paul Marjoram, Justin O Borevitz, Simon Tavaré

Abstract read
In one paragraph

Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rong JiangMolecular and Computational Biology Program, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90089, USA.
Paul Marjoram
Justin O Borevitz
Simon Tavaré

Funding

Implications of haplotype structure in the human genomeP50HG002790 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TAVARE, SIMON · 2003 to 2013
$29.9M
Computational Methods for Fine MappingR01GM069890 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MARJORAM, PAUL · 2004 to 2007
$1.9M
Computational Methods for Functional GenomicsR01GM067243 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TAVARE, SIMON · 2002 to 2005
$1.6M
NHGRI NIH HHS HG002790NHGRI NIH HHS P50 HG002790NIGMS NIH HHS GM069890NIGMS NIH HHS GM67243NIGMS NIH HHS R01 GM067243NIGMS NIH HHS R01 GM069890
6 · The paper itself

Abstract

This article is concerned with a statistical modeling procedure to call single-feature polymorphisms from microarray experiments. We use this new type of polymorphism data to estimate the mutation and recombination parameters in a population. The mutation parameter can be estimated via the number of single-feature polymorphisms called in the sample. For the recombination parameter, a two-feature sampling distribution is derived in a way analogous to that for the two-locus sampling distribution with SNP data. The approximate-likelihood approach using the two-feature sampling distribution is examined and found to work well. A coalescent simulation study is used to investigate the accuracy and robustness of our method. Our approach allows the utilization of single-feature polymorphism data for inference in population genetics.

Indexed as

Models, GeneticPolymorphism, Single NucleotideRecombination, GeneticArabidopsisComputer SimulationDNA, PlantOligonucleotide Array Sequence AnalysisQuantitative Trait LociDNA, Plant

Identifiers

PMID16702439
PMCPMC1569697

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.