ArticleGenetics2006
Parallel changes in global protein profiles during long-term experimental evolution in Escherichia coli.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 116 citations in OpenAlex.
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- Evolution of a cross-feeding interaction following a key innovation in a long-term evolution experiment withMicrobiology (Reading, England) · 2023Article
- The landscape of transcriptional and translational changes over 22 years of bacterial adaptation.eLife · 2022Article
- Dynamics of genetic variation in transcription factors and its implications for the evolution of regulatory networks in Bacteria.Nucleic acids research · 2020Article
- Accelerated evolution at chaperone promoters among Antarctic notothenioid fishes.BMC evolutionary biology · 2019Article
- Trusting the hand that feeds: microbes evolve to anticipate a serial transfer protocol as individuals or collectives.BMC evolutionary biology · 2019Article
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- Quantifying the benefit of a proteome reserve in fluctuating environments.Nature communications · 2017Article
- Experimental evolution and the dynamics of adaptation and genome evolution in microbial populations.The ISME journal · 2017Review
- Predicting metabolic adaptation from networks of mutational paths.Nature communications · 2017Article
- Core Genes Evolve Rapidly in the Long-Term Evolution Experiment with Escherichia coli.Genome biology and evolution · 2017Article
- Evolutionary switches between two serine codon sets are driven by selection.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Rapid genomic changes in Drosophila melanogaster adapting to desiccation stress in an experimental evolution system.BMC genomics · 2016Article
- Replaying the tape of life in the twenty-first century.Interface focus · 2015Review
- Bacterial transcriptome reorganization in thermal adaptive evolution.BMC genomics · 2015Article
- Elucidating the molecular architecture of adaptation via evolve and resequence experiments.Nature reviews. Genetics · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twelve populations of Escherichia coli evolved in and adapted to a glucose-limited environment from a common ancestor. We used two-dimensional protein electrophoresis to compare two evolved clones, isolated from independently derived populations after 20,000 generations. Exceptional parallelism was detected. We compared the observed changes in protein expression profiles with previously characterized global transcription profiles of the same clones; this is the first time such a comparison has been made in an evolutionary context where these changes are often quite subtle. The two methodologies exhibited some remarkable similarities that highlighted two different levels of parallel regulatory changes that were beneficial during the evolution experiment. First, at the higher level, both methods revealed extensive parallel changes in the same global regulatory network, reflecting the involvement of beneficial mutations in genes that control the ppGpp regulon. Second, both methods detected expression changes of identical gene sets that reflected parallel changes at a lower level of gene regulation. The protein profiles led to the discovery of beneficial mutations affecting the malT gene, with strong genetic parallelism across independently evolved populations. Functional and evolutionary analyses of these mutations revealed parallel phenotypic decreases in the maltose regulon expression and a high level of polymorphism at this locus in the evolved populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.