ArticleGenetics2006
High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Systems genetics of lifespan and senescence in Drosophila melanogaster.BMC biology · 2025Article
- Article
- Genetic, Environmental, and Stochastic Components of Lifespan Variability: TheInternational journal of molecular sciences · 2024Review
- Genetic Basis of Increased Lifespan and Postponed Senescence inG3 (Bethesda, Md.) · 2020Article
- Context-dependent genetic architecture of Drosophila life span.PLoS biology · 2020Article
- Review
- Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity acrossGenome research · 2019Article
- Regulation of Drosophila Lifespan by bellwether Promoter Alleles.Scientific reports · 2017Article
- Genetic analysis of variation in lifespan using a multiparental advanced intercross Drosophila mapping population.BMC genetics · 2016Article
- Article
- Genomic response to selection for postponed senescence in Drosophila.Mechanisms of ageing and development · 2013Article
- Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression and function of an aquaporin.PLoS genetics · 2012Article
- Article
- Mutations and quantitative genetic variation: lessons from Drosophila.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Integrating evolutionary and molecular genetics of aging.Biochimica et biophysica acta · 2009Review
- What can genetic variation tell us about the evolution of senescence?Proceedings. Biological sciences · 2009Article
- Genetic architecture of quantitative traits in mice, flies, and humans.Genome research · 2009Article
- Functional significance of allelic variation at methuselah, an aging gene in Drosophila.PloS one · 2008Article
- Drosophila aging 2006/2007.Experimental gerontology · 2008Review
- Drosophotoxicology: the growing potential for Drosophila in neurotoxicology.Neurotoxicology and teratologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Limited life span and senescence are near-universal characteristics of eukaryotic organisms, controlled by many interacting quantitative trait loci (QTL) with individually small effects, whose expression is sensitive to the environment. Analyses of mutations in model organisms have shown that genes affecting stress resistance and metabolism affect life span across diverse taxa. However, there is considerable segregating variation for life span in nature, and relatively little is known about the genetic basis of this variation. Replicated lines of Drosophila that have evolved increased longevity as a correlated response to selection for postponed senescence are valuable resources for identifying QTL affecting naturally occurring variation in life span. Here, we used deficiency complementation mapping to identify at least 11 QTL on chromosome 3 that affect variation in life span between five old (O) lines selected for postponed senescence and their five base (B) population control lines. Most QTL were sex specific, and all but one affected multiple O lines. The latter observation is consistent with alleles at intermediate frequency in the base population contributing to the response to selection for postponed senescence. The QTL were mapped with high resolution and contained from 12 to 170 positional candidate genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.