ArticleGenetics2006
The Hill-Robertson effect and the evolution of recombination.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- The Evolution of Locally Adaptive Chromosome Inversions in Mimulus guttatus.Molecular ecology · 2025Article
- Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation.Science (New York, N.Y.) · 2025Article
- Selection Can Favor a Recombination Landscape That Limits Polygenic Adaptation.Molecular biology and evolution · 2025Article
- Competing adaptations maintain nonadaptive variation in a wild cricket population.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Increased Positive Selection in Highly Recombining Genes Does not Necessarily Reflect an Evolutionary Advantage of Recombination.Molecular biology and evolution · 2024Article
- Directional selection coupled with kin selection favors the establishment of senescence.BMC biology · 2023Article
- Repeat sequences limit the effectiveness of lateral gene transfer and favored the evolution of meiotic sex in early eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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- Highly Parallel Genomic Selection Response in Replicated Drosophila melanogaster Populations with Reduced Genetic Variation.Genome biology and evolution · 2021Article
- Seasonal changes in recombination characteristics in a natural population of Drosophila melanogaster.Heredity · 2021Article
- Locally Adaptive Inversions Modulate Genetic Variation at Different Geographic Scales in a Seaweed Fly.Molecular biology and evolution · 2021Article
- A simple expression for the strength of selection on recombination generated by interference among mutations.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Application of simultaneous selective pressures slows adaptation.Evolutionary applications · 2020Article
- Population genomics of Vibrionaceae isolated from an endangered oasis reveals local adaptation after an environmental perturbation.BMC genomics · 2020Article
- Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence.Cell host & microbe · 2020Article
- A Population Genomics Lexicon.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Crossover Interference: Shedding Light on the Evolution of Recombination.Annual review of genetics · 2019Review
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In finite populations, genetic drift generates interference between selected loci, causing advantageous alleles to be found more often on different chromosomes than on the same chromosome, which reduces the rate of adaptation. This "Hill-Robertson effect" generates indirect selection to increase recombination rates. We present a new method to quantify the strength of this selection. Our model represents a new beneficial allele (A) entering a population as a single copy, while another beneficial allele (B) is sweeping at another locus. A third locus affects the recombination rate between selected loci. Using a branching process model, we calculate the probability distribution of the number of copies of A on the different genetic backgrounds, after it is established but while it is still rare. Then, we use a deterministic model to express the change in frequency of the recombination modifier, due to hitchhiking, as A goes to fixation. We show that this method can give good estimates of selection for recombination. Moreover, it shows that recombination is selected through two different effects: it increases the fixation probability of new alleles, and it accelerates selective sweeps. The relative importance of these two effects depends on the relative times of occurrence of the beneficial alleles.
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