ArticleGenetics2006
The effect of gap length on double-strand break repair in Drosophila.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Review
- Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila.PLoS genetics · 2012Article
- Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster.Genetics · 2011Article
- A recombination execution checkpoint regulates the choice of homologous recombination pathway during DNA double-strand break repair.Genes & development · 2009Article
- Article
- Article
- In vivo construction of transgenes in Drosophila.Genetics · 2007Article
- Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
When a double-strand break has a gap between the broken ends, the missing information can be restored through synthesis from a homologous template. Here we address the question of how long such a gap can be before this process fails. We measured the frequency of homologous repair in the Drosophila germ line following the creation of gaps of specific sizes ranging from 3.8 to 210 kb. We found that gaps of <or=11 kb can be repaired with approximately the same efficiency as breaks with no gap at all. However, a gap of 44 kb was repaired only rarely, and one of 210 kb was not repaired at a measurable frequency. We conclude that DNA gap repair is a length-limited process, but that this limitation is critical only for gaps>>11 kb.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.