ArticleJournal of clinical pathology2007
The role of immunohistochemistry for smooth-muscle actin, p63, CD10 and cytokeratin 14 in the differential diagnosis of papillary lesions of the breast.
Article in Journal of clinical pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 70 citations in OpenAlex.
- Inverse Association of p63 Expression with Hormone Receptor Status in Invasive Breast Cancer.Journal of personalized medicine · 2026Article
- Reliability of stromal markers multiplex immunofluorescent staining: pathologist assessment compared to quantitative image analysis.American journal of cancer research · 2026Article
- Expression of alpha-smooth muscle actin in salivary mucoepidermoid and adenoid cystic carcinomas: A comparative immunohistochemical study.Journal of Taibah University Medical Sciences · 2025Article
- Knowledge of mucin immunostaining status of "nuclear inverse polarity papillary lesions lacking myoepithelial cells" may prevent unnecessary breast surgery: experience of two cases.The Journal of international medical research · 2023Article
- Dimorphic cells: a common feature throughout the low nuclear grade breast neoplasia spectrum.Virchows Archiv : an international journal of pathology · 2023Article
- Prognostic value of the immunohistochemical score based on four markers in head and neck squamous cell carcinoma.Frontiers in immunology · 2023Article
- [Pathology of the nipple-areola complex : Part II. Tumors, tumor-like lesions, and supernumerary breast lesions].Der Pathologe · 2020Review
- CXCL1 Derived from Mammary Fibroblasts Promotes Progression of Mammary Lesions to Invasive Carcinoma through CXCR2 Dependent Mechanisms.Journal of mammary gland biology and neoplasia · 2018Article
- Spatially correlated phenotyping reveals K5-positive luminal progenitor cells and p63-K5/14-positive stem cell-like cells in human breast epithelium.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast.SAGE open medicine · 2018Article
- Application of Returned Cell Block Method (Cell Block from a Papanicolaou Staining Smear on a Glass Slide) for the Evaluation of Fine Needle Aspiration Cytology of Tumors of the Breast.Diagnostic cytopathology · 2016Article
- Article
- Immunostaining of ∆Np63 (using the p40 antibody) is equal to that of p63 and CK5/6 in high-grade ductal carcinoma in situ of the breast.Virchows Archiv : an international journal of pathology · 2015Article
- [Diagnostics of benign ductal epithelial cell proliferation of the breast in biopsy material].Der Pathologe · 2014Review
- CD10-positive malignant spindle cell tumor of the lip in a child: a malignant myoepithelioma?International journal of clinical and experimental pathology · 2013Article
- Histological analysis of benign breast imaging reporting and data system categories 4c and 5 breast lesions in imaging study.Yonsei medical journal · 2012Article
- Myoepithelial Carcinoma: A Rare Neoplasm of the Breast.Breast care (Basel, Switzerland) · 2010Article
- Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with intraductal papilloma with usual ductal hyperplasia.Virchows Archiv : an international journal of pathology · 2007Article
- Utility of smooth muscle actin and CD117 as reliable markers in the diagnosis of salivary gland neoplasms.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHistological differentiation of mammary papillary lesions can be difficult. The evaluation of myoepithelial cells can be helpful, with benign papilloma showing a continuous myoepithelial cell layer, which becomes attenuated or absent in malignant papillary lesions.
methodsA large series of 100 papillomas (28 papillomas with florid epithelial hyperplasia) and 68 papillary carcinomas (9 invasive, 44 in situ, and 15 ductal carcinomas in situ (DCIS) involving papillomas) of the breast were stained for myoepithelial cells by immunohistochemistry using antibodies to smooth-muscle actin (SMA), p63, CD10 and cytokeratin (CK) 14.
resultsIn the papillomas, using these four antibodies, myoepithelial cells were positive in 88%, 99%, 91% and 95% of cases, respectively, with SMA showing marked stromal component cell staining and CD10 showing epithelial and stromal staining. CK14 also showed epithelial staining in 71% of papillomas and 96% of papillomas with florid epithelial hyperplasia. In the papillary carcinomas, 36 (53%) cases showed staining of myoepithelial cells that were scattered, discontinuous and diminished in number and the remaining 32 (47%) cases did not show myoepithelial cells. Invasive papillary carcinoma has the lowest proportion (33%) with myoepithelial cells, and DCIS involving papillomas had the highest proportion (87%).
conclusionsp63 had the highest sensitivity and did not cross-react with stromal cells and only rarely with epithelial cells. CK14 has the added ability to distinguish between florid epithelial hyperplasia involving papilloma and DCIS involving papillomas. CK14 and p63 may be used as an adjunct in assessing difficult papillary lesions of the breast.
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