ArticleJournal of clinical pathology2007
Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis.
Article in Journal of clinical pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 87 citations in OpenAlex.
- Topical administration of S. salivarius 24SMB-S. oralis 89a in children with adenoidal disease: a double-blind controlled trial.European journal of pediatrics · 2024Trial
- 1-year follow-up after radiofrequency tonsillotomy and laser tonsillotomy in children: a prospective, double-blind, clinical study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2012Trial
- The Clinical Role of the Adenoid Microbiome in the Development of Adenoid Hypertrophy and Otitis Media with Effusion.Journal of clinical medicine · 2026Article
- Molecular and Drug Resistance Characteristics ofMicroorganisms · 2025Article
- [Exploring local microbial communities in adenoids through 16S rRNA gene sequencing].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Differences in salivary microbiome among children with tonsillar hypertrophy and/or adenoid hypertrophy.mSystems · 2024Article
- Changes in the nasopharyngeal and oropharyngeal microbiota in pediatric obstructive sleep apnea before and after surgery: a prospective study.BMC microbiology · 2024Article
- Bacteriological Profile of Chronic Rhinosinusitis and Adenotonsillitis: Evaluating the Role of Biofilm Production and Multidrug Resistance.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Unveiling the Enigmatic Adenoids and Tonsils: Exploring Immunology, Physiology, Microbiome Dynamics, and the Transformative Power of Surgery.Microorganisms · 2023Review
- Fluorescence in situ hybridisation in Carnoy's fixed tonsil tissue.Scientific reports · 2022Article
- Inflammatory bowel disease-related colorectal cancer: Past, present and future perspectives.World journal of gastrointestinal oncology · 2022Review
- Article
- Respiratory and Neurological Disease across Different Ethnic Groups Is Influenced by the Microbiome.Microorganisms · 2021Review
- A Correlation Study of the Microbiota Between Oral Cavity and Tonsils in Children With Tonsillar Hypertrophy.Frontiers in cellular and infection microbiology · 2021Article
- Distinct microbial communities colonize tonsillar squamous cell carcinoma.Oncoimmunology · 2021Article
- Review of otitis media microbiome studies: What do they tell us?Laryngoscope investigative otolaryngology · 2020Review
- Comparative analysis of the tonsillar microbiota in IgA nephropathy and other glomerular diseases.Scientific reports · 2020Article
- Singularities of Pyogenic Streptococcal Biofilms - From Formation to Health Implication.Frontiers in microbiology · 2020Review
- A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow.Nature communications · 2018Article
- The Relationship between Colonization byThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe reasons for recurrent adenotonsillitis are poorly understood.
methodsThe in situ composition of microbiota of nasal (5 children, 25 adults) and of hypertrophied adenoid and tonsillar tissue (50 children, 20 adults) was investigated using a broad range of fluorescent oligonucleotide probes targeted to bacterial rRNA. None of the patients had clinical signs of infection at the time of surgery.
resultsMultiple foci of ongoing purulent infections were found within hypertrophied adenoid and tonsillar tissue in 83% of patients, including islands and lawns of bacteria adherent to the epithelium, with concomitant marked inflammatory response, fissures filled with bacteria and pus, and diffuse infiltration of the tonsils by bacteria, microabscesses, and macrophages containing phagocytosed microorganisms. Haemophilusinfluenzae mainly diffusely infiltrated the tissue, Streptococcus and Bacteroides were typically found in fissures, and Fusobacteria,Pseudomonas and Burkholderia were exclusively located within adherent bacterial layers and infiltrates. The microbiota were always polymicrobial.
conclusionsPurulent processes persist during asymptomatic periods of adenotonsillitis. Most bacteria involved in this process are covered by a thick inflammatory infiltrate, are deeply invading, or are located within macrophages. The distribution of the bacteria within tonsils may be responsible for the failure of antibiotic treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.