ArticleThe Plant cell2006
Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- HD-Zip IV transcription factors: Drivers of epidermal cell fate integrate metabolic signals.Current opinion in plant biology · 2023Review
- Fumonisin B1 as a Tool to Explore Sphingolipid Roles in Arabidopsis Primary Root Development.International journal of molecular sciences · 2022Article
- The UBP14-CDKB1;1-CDKG2 cascade controls endoreduplication and cell growth in Arabidopsis.The Plant cell · 2022Article
- Disruption of Very-Long-Chain-Fatty Acid Synthesis Has an Impact on the Dynamics of Cellulose Synthase inPlants (Basel, Switzerland) · 2020Article
- Plant tumors: a hundred years of study.Planta · 2020Review
- Synthesis of very-long-chain fatty acids in the epidermis controls plant organ growth by restricting cell proliferation.PLoS biology · 2013Article
- Auxin and ABA act as central regulators of developmental networks associated with paradormancy in Canada thistle (Cirsium arvense).Functional & integrative genomics · 2012Article
- Extensive changes to alternative splicing patterns following allopolyploidy in natural and resynthesized polyploids.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Signal processing by protein tyrosine phosphorylation in plants.Plant signaling & behavior · 2011Review
- EGG molecules couple the oocyte-to-embryo transition with cell cycle progression.Results and problems in cell differentiation · 2011Review
- The Sos-recruitment system as a tool to analyze cellular localization of plant proteins: membrane localization of Arabidopsis thaliana PEPINO/PASTICCINO2.Molecular genetics and genomics : MGG · 2010Article
- Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis.The Plant cell · 2010Article
- Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1.The Plant cell · 2009Article
- Article
- CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset.Plant physiology · 2009Article
- The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis.PloS one · 2007Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PASTICCINO2 (PAS2), a member of the protein Tyr phosphatase-like family, is conserved among all eukaryotes and is characterized by a mutated catalytic site. The cellular functions of the Tyr phosphatase-like proteins are still unknown, even if they are essential in yeast and mammals. Here, we demonstrate that PAS2 interacts with a cyclin-dependent kinase (CDK) that is phosphorylated on Tyr and not with its unphosphorylated isoform. Phosphorylation of the conserved regulatory Tyr-15 is involved in the binding of CDK to PAS2. Loss of the PAS2 function dephosphorylated Arabidopsis thaliana CDKA;1 and upregulated its kinase activity. In accordance with its role as a negative regulator of the cell cycle, overexpression of PAS2 slowed down cell division in suspension cell cultures at the G2-to-M transition and early mitosis and inhibited Arabidopsis seedling growth. The latter was accompanied by altered leaf development and accelerated cotyledon senescence. PAS2 was localized in the cytoplasm of dividing cells but moved into the nucleus upon cell differentiation, suggesting that the balance between cell division and differentiation is regulated through the interaction between CDKA;1 and the antiphosphatase PAS2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.