ArticleProceedings of the National Academy of Sciences of the United States of America2006
Differentiation of proteins based on characteristic patterns of association and denaturation in solutions of SDS.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
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- Development and Characterization of a Fluorinated MS-Cleavable Cross-Linker for Structural Proteomics.Journal of the American Society for Mass Spectrometry · 2025Article
- Synthetic and biological surfactant effects on freshwater biofilm community composition and metabolic activity.Applied microbiology and biotechnology · 2022Article
- Comparison of separation modes for microchip electrophoresis of proteins.Journal of separation science · 2021Article
- An Electrochemical Chip to Monitor In Vitro Glycation of Proteins and Screening of Antiglycation Potential of Drugs.Pharmaceutics · 2020Article
- An integrative toolbox to unlock the structure and dynamics of protein-surfactant complexes.Nanoscale advances · 2020Article
- Effects of Ionic Liquid Alkyl Chain Length on Denaturation of Myoglobin by Anionic, Cationic, and Zwitterionic Detergents.Biomolecules · 2019Article
- Determination of Protein Haptenation by Chemical Sensitizers Within the Complexity of the Human Skin Proteome.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Aptamers Selected for Recognizing Amyloid β-Protein-A Case for Cautious Optimism.International journal of molecular sciences · 2018Review
- Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.Nature communications · 2015Article
- Two promising alkaline β-glucosidases isolated by functional metagenomics from agricultural soil, including one showing high tolerance towards harsh detergents, oxidants and glucose.Journal of industrial microbiology & biotechnology · 2014Article
- Dilution of protein-surfactant complexes: a fluorescence study.Protein science : a publication of the Protein Society · 2013Article
- Effect of surfactant hydrophobicity on the pathway for unfolding of ubiquitin.Journal of the American Chemical Society · 2012Article
- Complexes of native ubiquitin and dodecyl sulfate illustrate the nature of hydrophobic and electrostatic interactions in the binding of proteins and surfactants.Journal of the American Chemical Society · 2011Article
- Size separation of proteins by capillary zone electrophoresis with cationic hitchhiking.Electrophoresis · 2011Article
- Denaturation of proteins by SDS and tetraalkylammonium dodecyl sulfates.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Identifying kinetically stable proteins with capillary electrophoresis.Protein science : a publication of the Protein Society · 2010Article
- Inactivation and unfolding of the hyperthermophilic inorganic pyrophosphatase from Thermus thermophilus by sodium dodecyl sulfate.International journal of molecular sciences · 2009Article
- Pathway for unfolding of ubiquitin in sodium dodecyl sulfate, studied by capillary electrophoresis.Journal of the American Chemical Society · 2008Article
- Capillary electrophoresis in bioanalysis.Analytical chemistry · 2008Review
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Authors and funding
3 authors.
Funding
Abstract
This paper shows that proteins display an unexpectedly wide range of behaviors in buffers containing moderate (0.1-10 mM) concentrations of SDS (complete unfolding, formation of stable intermediate states, specific association with SDS, and various kinetic phenomena); capillary electrophoresis provides a convenient method of examining these behaviors. Examination of the dynamics of the response of proteins to SDS offers a way to differentiate and characterize proteins. Based on a survey of 18 different proteins, we demonstrate that proteins differ in the concentrations of SDS at which they denature, in the rates of unfolding in SDS, and in the profiles of the denaturation pathways. We also demonstrate that these differences can be exploited in the analysis of mixtures.
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