Evidence map›Paper›PMID 16698786›Full record

ArticleBiophysical journal2006

Tryptophan rotamers as evidenced by X-ray, fluorescence lifetimes, and molecular dynamics modeling.

Samuel L C Moors, Mario Hellings, Marc De Maeyer, Yves Engelborghs, Arnout Ceulemans

Abstract read
In one paragraph

Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. AlphaFold2-RAVE: From Sequence to Boltzmann Ranking.Journal of chemical theory and computation · 2023
    Article
  2. Thin-Plate Superstructures of the Immunogenic 33-mer Gliadin Peptide.Chembiochem : a European journal of chemical biology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samuel L C MoorsLaboratory of Quantum Chemistry, University of Leuven, Leuven, Belgium.
Mario Hellings
Marc De Maeyer
Yves Engelborghs
Arnout Ceulemans

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the native-state dynamics of the Bacillus caldolyticus cold-shock protein mutant Bc-Csp L66E, using fluorescence and appropriate molecular dynamics methods. Two fluorescence lifetimes were found, the amplitudes of which agree very well with tryptophan rotamer populations, obtained from parallel tempering calculations. Rotamer lifetimes were predicted by transition-state theory from high-temperature simulations. Transition pathways were extracted from the transition rates between individual rotameric states. The molecular dynamics also reveal the loop fluctuations in the native state.

Indexed as

AcrylamideBacillusBiophysicsKineticsModels, MolecularModels, StatisticalMutationSolventsSpectrometry, FluorescenceThermodynamicsTime FactorsTryptophanX-RaysAcrylamideSolventsTryptophan

Identifiers

PMID16698786
PMCPMC1563760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.