ReviewFEMS yeast research2006
Phenotypic switching and its implications for the pathogenesis of Cryptococcus neoformans.
Review in FEMS yeast research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- HYPHAEdelity: a quantitative image analysis tool for assessing peripheral whole colony filamentation.FEMS yeast research · 2022Article
- Coupled Feedback Loops Involving PAGE4, EMT and Notch Signaling Can Give Rise to Non-genetic Heterogeneity in Prostate Cancer Cells.Entropy (Basel, Switzerland) · 2021Article
- Incorporation of 2-amino-thiophene derivative in nanoparticles: enhancement of antifungal activity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- A spontaneous mutation in DNA polymerase POL3 during in vitro passaging causes a hypermutator phenotype in Cryptococcus species.DNA repair · 2020Article
- Fungal biofilm morphology impacts hypoxia fitness and disease progression.Nature microbiology · 2019Article
- Longitudinal Changes in Cd4Journal of fungi (Basel, Switzerland) · 2019Article
- Cryptococcal Traits Mediating Adherence to Biotic and Abiotic Surfaces.Journal of fungi (Basel, Switzerland) · 2018Review
- Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans.Scientific reports · 2017Article
- Aging as an emergent factor that contributes to phenotypic variation in Cryptococcus neoformans.Fungal genetics and biology : FG & B · 2015Review
- Aging: an emergent phenotypic trait that contributes to the virulence of Cryptococcus neoformans.Future microbiology · 2015Article
- Antifungal activity of topical microemulsion containing a thiophene derivative.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species.Eukaryotic cell · 2013Article
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier.PLoS pathogens · 2013Article
- Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells.PloS one · 2012Article
- Gliotoxin in Aspergillus fumigatus: an example that mycotoxins are potential virulence factors.Mycotoxin research · 2009Article
- Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans.Genome biology · 2008Article
- Synthesis of cell envelope glycoproteins of Cryptococcus laurentii.Carbohydrate research · 2007Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Phenotypic switching has been described in several strains of Cryptococcus neoformans. It occurs in vivo during chronic infection and is associated with differential gene expression and changes in virulence. The switch involves changes in the polysaccharide capsule and cell wall that affect the yeast's ability to resist phagocytosis. In addition, the phenotypic switch variants elicit qualitatively different inflammatory responses in the host. The host's immune response ultimately affects selection of the switch variants in animal models of chronic cryptococcosis. The biological relevance of phenotypic switching is demonstrated in several murine infection models and further underlines the importance of phenotypic switching in the setting of human disease. This includes the association of switching and poor outcome in chronic infection, the ability of the mucoid variant of strain RC-2 (RC-2 MC) but not the smooth variant (RC-2 SM) to promote increased intracranial pressure in a rat model, and lastly the observation that antifungal interventions can promote the selection of more virulent switch variants during chronic murine infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.