ArticleGlycoconjugate journal2006
Role of C-reactive protein in complement-mediated hemolysis in Malaria.
Article in Glycoconjugate journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis.Scientific reports · 2021Pooled it
- Distinct systemic cytokine signatures define symptomatic malaria in children: insights from a longitudinal study in Togo.BMC infectious diseases · 2026Article
- Differences in Immunological and Inflammatory Biomarkers Levels in People Infected withAdvanced biomedical research · 2026Article
- Protective Vaccination of Mice Against Blood-Stage Malaria Impacts Hepatic Expression of Genes Encoding Acute-Phase Proteins and IL-6 Family Members.International journal of molecular sciences · 2025Article
- Biomarkers of disease severity in vivax malaria.Parasitology research · 2021Article
- C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc ReceptorsFrontiers in immunology · 2021Article
- High-Sensitivity C-Reactive Protein: A Potential Ancillary Biomarker for Malaria Diagnosis and Morbidity.Disease markers · 2019Article
- The usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African region.PloS one · 2018Article
- Elevated Values of C-Reactive Protein Induced by Imported Infectious Diseases: A Controlled Cross-Sectional Study of 11,079 Diseased German Travelers Returning from the Tropics and Subtropics.The American journal of tropical medicine and hygiene · 2016Article
- Hemoparasites in a wild primate: Infection patterns suggest interaction of Plasmodium and Babesia in a lemur species.International journal for parasitology. Parasites and wildlife · 2015Article
- Congenital malaria in a neonate: case report with a comprehensive review on differential diagnosis, treatment and prevention in Indian perspective.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- C-reactive protein and the biology of disease.Immunologic research · 2013Review
- Study of C reactive protein as a prognostic marker in malaria from Eastern India.Advanced biomedical research · 2012Article
- Suppression of Plasmodium cynomolgi in rhesus macaques by coinfection with Babesia microti.Infection and immunity · 2010Article
- Disease-associated glycosylated molecular variants of human C-reactive protein activate complement-mediated hemolysis of erythrocytes in tuberculosis and Indian visceral leishmaniasis.Glycoconjugate journal · 2009Article
- Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa.Malaria journal · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human C-reactive protein (CRP) is a clinically important classical acute phase protein. Although CRP has been reported to bind with many nucleated cells, the direct binding of CRP to erythrocytes in diseases remains largely unexplored. The main focus of the present study was to investigate the binding of disease-specific CRP to erythrocytes of same patients. Distinct molecular variant of disease-specific CRP was affinity purified from sera of malaria patients (CRP(Mal)). This CRP showed strong binding with malaria erythrocytes (RBC(Mal)) as confirmed by flow cytometric analysis (FACS), enzyme-linked immunosorbent assays (ELISA), and radio binding assays. Calcium and phosphoryl choline (PC) were found to be essential for this interaction. A 2.3-fold increased binding of induced CRP to RBC(Mal) as compared to normal erythrocytes (RBC(N)) confirmed disease-specificity. Preincubation of RBC(Mal) with unconjugated CRP showed 3-5 fold inhibition. The association constant of CRP and RBC(Mal) was 4.7 x 10(6) cpm/microg with the corresponding number of receptors/cell being 4.3 x 10(5). The effector function of CRP(Mal) has been demonstrated by its potency to activate the complement pathway. An optimal dose of 10 microg/ml of CRP induced three-fold higher hemolysis of patient erythrocytes as compared to RBC(N). These studies provide direct evidence for an important phagocytic functional interaction of this acute-phase protein by triggering the CRP-complement pathway after the binding of CRP(Mal) with RBC(Mal). Hemolysis as triggered by this pathway may be one of the causative factors of anemia, a common clinical manifestation of this disease.
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