ArticleCellular and molecular neurobiology
Spatiotemporal organization of Ras signaling: rasosomes and the galectin switch.
Article in Cellular and molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- Intracellular galectin interactions in health and disease.Seminars in immunopathology · 2024Review
- The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target.International journal of molecular sciences · 2023Review
- Review
- Galectin-3 (MAC-2) controls phagocytosis and macropinocytosis through intracellular and extracellular mechanisms.Frontiers in cellular neuroscience · 2022Review
- Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis.Journal of experimental & clinical cancer research : CR · 2021Article
- Article
- Decoding the sweet regulation of apoptosis: the role of glycosylation and galectins in apoptotic signaling pathways.Cell death and differentiation · 2019Review
- Ras and exosome signaling.Seminars in cancer biology · 2019Review
- Concepts and advances in cancer therapeutic vulnerabilities in RAS membrane targeting.Seminars in cancer biology · 2019Review
- Galectins as Molecular Targets for Therapeutic Intervention.International journal of molecular sciences · 2018Review
- Potato Mop-Top Virus Co-Opts the Stress Sensor HIPP26 for Long-Distance Movement.Plant physiology · 2018Article
- Review
- Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced ArthritisFrontiers in immunology · 2017Article
- Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.Scientific reports · 2016Article
- Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Review
- Rasosomes originate from the Golgi to dispense Ras signals.Cell death & disease · 2013Article
- Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis.Oncotarget · 2013Article
- The roles of Galectin-3 in autoimmunity and tumor progression.Immunologic research · 2012Review
- Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling.PloS one · 2012Article
- Wallerian degeneration: the innate-immune response to traumatic nerve injury.Journal of neuroinflammation · 2011Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Ras signaling and oncogenesis depend on the dynamic interplay of Ras with distinctive plasma membrane (PM) microdomains and various intracellular compartments. Such interaction is dictated by individual elements in the carboxy-terminal domain of the Ras proteins, including a farnesyl isoprenoid group, sequences in the hypervariable region (hvr)-linker, and palmitoyl groups in H/N-Ras isoforms. 2. The farnesyl group acts as a specific recognition unit that interacts with prenyl-binding pockets in galectin-1 (Gal-1), galectin-3 (Gal-3), and cGMP phosphodiesterase delta. This interaction appears to contribute to the prolongation of Ras signals in the PM, the determination of Ras effector usage, and perhaps also the transport of cytoplasmic Ras. Gal-1 promotes H-Ras signaling to Raf at the expense of phosphoinositide 3-kinase (PI3-K) and Ral guanine nucleotide exchange factor (RalGEF), while galectin-3 promotes K-Ras signaling to both Raf and PI3-K. 3. The hvr-linker and the palmitates of H-Ras and N-Ras determine the micro- and macro-localizations of these proteins in the PM and in the Golgi, as well as in 'rasosomes', randomly moving nanoparticles that carry palmitoylated Ras proteins and their signal through the cytoplasm.4. The dynamic compartmentalization of Ras proteins contributes to the spatial organization of Ras signaling, promotes redistribution of Ras, and provides an additional level of selectivity to the signal output of this regulatory GTPase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.