ReviewPflugers Archiv : European journal of physiology2006
Functions of neuronal P2Y receptors.
Review in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Exploring Astrocyte-Mediated Mechanisms in Sleep Disorders and Comorbidity.Biomedicines · 2023Review
- Mechanisms of sympathoexcitationFrontiers in pharmacology · 2022Article
- Astrocytes-The Ultimate Effectors of Long-Range Neuromodulatory Networks?Frontiers in cellular neuroscience · 2020Article
- Membrane coordination of receptors and channels mediating the inhibition of neuronal ion currents by ADP.Purinergic signalling · 2016Article
- Loss of P2Y₂ nucleotide receptors enhances early pathology in the TgCRND8 mouse model of Alzheimer's disease.Molecular neurobiology · 2014Article
- Neuroprotective roles of the P2Y(2) receptor.Purinergic signalling · 2012Review
- Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system.Frontiers in physiology · 2012Article
- Article
- Regional expression of P2Y(4) receptors in the rat central nervous system.Purinergic signalling · 2011Article
- Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors.British journal of pharmacology · 2011Article
- Article
- P2Y purinergic regulation of the glycine neurotransmitter transporters.The Journal of biological chemistry · 2011Article
- The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors.Molecular pain · 2011Article
- ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors.Molecular pharmacology · 2010Article
- P2Y1 receptors mediate an activation of neuronal calcium-dependent K+ channels.The Journal of physiology · 2010Article
- Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment.British journal of pharmacology · 2010Review
- Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- P2X3 receptor involvement in pain states.Molecular neurobiology · 2007Review
- P2 receptor-mediated modulation of neurotransmitter release-an update.Purinergic signalling · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within the last 15 years, at least eight different G protein-coupled nucleotide receptors, i.e., P2Y receptors, have been characterized by molecular means. While ionotropic P2X receptors are mainly involved in fast synaptic neurotransmission, P2Y receptors rather mediate slower neuromodulatory effects. This P2Y receptor-dependent neuromodulation relies on changes in synaptic transmission via either pre- or postsynaptic sites of action. At both sites, the regulation of voltage-gated or transmitter-gated ion channels via G protein-linked signaling cascades has been identified as the predominant underlying mechanisms. In addition, neuronal P2Y receptors have been found to be involved in neurotoxic and neurotrophic effects of extracellular adenosine 5-triphosphate. This review provides an overview of the most prominent actions mediated by neuronal P2Y receptors and describes the signaling cascades involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.