ArticleGenes and immunity2006
High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis.Rheumatology international · 2010Pooled it
- Meta-analysis of genome-wide linkage studies across autoimmune diseases.European journal of human genetics : EJHG · 2009Pooled it
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- Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus.Biomolecules · 2020Review
- A TRAF6 genetic variant is associated with low bone mineral density in rheumatoid arthritis.Clinical rheumatology · 2019Article
- Genetic variants of TRAF6 modulate peritoneal immunity and the risk of spontaneous bacterial peritonitis in cirrhosis: A combined prospective-retrospective study.Scientific reports · 2017Article
- Rheumatoid arthritis susceptibility genes: An overview.World journal of orthopedics · 2014Review
- Expression of inducible co-stimulator on peripheral blood T lymphocytes in patients with lupus nephritis.Rheumatology international · 2012Article
- Evaluation of TRAF6 in a large multiancestral lupus cohort.Arthritis and rheumatism · 2012Article
- Identification of two new arthritis severity loci that regulate levels of autoantibodies, interleukin-1β, and joint damage in pristane- and collagen-induced arthritis.Arthritis and rheumatism · 2012Article
- Accuracy and computational efficiency of a graphical modeling approach to linkage disequilibrium estimation.Statistical applications in genetics and molecular biology · 2011Article
- Bayesian mixture models for the incorporation of prior knowledge to inform genetic association studies.Genetic epidemiology · 2010Article
- Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis.Genes and immunity · 2010Article
- Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis.Seminars in nephrology · 2010Article
- Evaluation of approaches to identify associated SNPs that explain the linkage evidence in nuclear families with affected siblings.Human heredity · 2010Article
- Use of supplementary phenotype to identify additional rheumatoid arthritis loci in a linkage analysis of 342 UK affected sibling pair families.BMC medical genetics · 2009Article
- Genome-wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome-wide linkage results.BMC proceedings · 2009Article
- Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling.BMC proceedings · 2009Article
- Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods.BMC proceedings · 2009Article
- Adjusting for HLA-DRbeta1 in a genome-wide association analysis of rheumatoid arthritis and related biomarkers.BMC proceedings · 2009Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
We have completed a genome wide linkage scan using >5700 informative single-nucleotide polymorphism (SNP) markers (Illumina IV SNP linkage panel) in 642 Caucasian families containing affected sibling pairs with rheumatoid arthritis (RA), ascertained by the North American Rheumatoid Arthritis Consortium. The results show striking new evidence of linkage at chromosomes 2q33 and 11p12 with logarithm of odds (LOD) scores of 3.52 and 3.09, respectively. In addition to a strong and broad linkage interval surrounding the major histocompatibility complex (LOD>16), regions with LOD>2.5 were observed on chromosomes 5 and 10. Additional linkage evidence (LOD scores between 1.46 and 2.35) was also observed on chromosomes 4, 7, 12, 16 and 18. This new evidence for multiple regions of genetic linkage is partly explained by the significantly increased information content of the Illumina IV SNP linkage panel (75.6%) compared with a standard microsatellite linkage panel utilized previously (mean 52.6%). Stratified analyses according to whether or not the sibling pair members showed elevated anticyclic citrullinated peptide titers indicates significant variation in evidence for linkage among strata on chromosomes 4, 5, 6 and 7. Overall, these new linkage data should reinvigorate efforts to utilize positional information to identify susceptibility genes for RA.
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Registered trials
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