ArticleGenes and immunity2006
Gene-expression profiling of HIV-1 infection and perinatal transmission in Botswana.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Heightened expression of type I interferon signaling genes in CD4Frontiers in immunology · 2024Article
- A robust host-response-based signature distinguishes bacterial and viral infections across diverse global populations.Cell reports. Medicine · 2022Article
- Gene Expression Profiling Reveals New Pathways and Genes Associated with Visna/Maedi Viral Disease.Animals : an open access journal from MDPI · 2021Article
- Gene Expression: the Key to Understanding HIV-1 Infection?Microbiology and molecular biology reviews : MMBR · 2020Review
- A curated transcriptome dataset collection to investigate the immunobiology of HIV infection.F1000Research · 2016Article
- The effect of cell subset isolation method on gene expression in leukocytes.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2014Article
- A derived network-based interferon-related signature of human macrophages responding to Mycobacterium tuberculosis.BioMed research international · 2014Article
- Geographical, environmental and pathophysiological influences on the human blood transcriptome.Current genetic medicine reports · 2013Article
- Article
- Gene array studies in HIV-1 infection.Current HIV/AIDS reports · 2012Review
- Analysis of HIV-1 expression level and sense of transcription by high-throughput sequencing of the infected cell.Journal of virology · 2011Article
- Current understanding of HIV-associated neurocognitive disorders pathogenesis.Current opinion in neurology · 2011Review
- Maternal influences on the transmission of leukocyte gene expression profiles in population samples from Brisbane, Australia.PloS one · 2010Article
- Antiretroviral therapy down-regulates innate antiviral response genes in patients with AIDS in sub-saharan Africa.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- The RNA editor gene ADAR1 is induced in myoblasts by inflammatory ligands and buffers stress response.Clinical and translational science · 2010Article
- Enhanced monocyte response and decreased central memory T cells in children with invasive Staphylococcus aureus infections.PloS one · 2009Article
- A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs.PLoS genetics · 2008Article
- CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection.Genes and immunity · 2007Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Perinatal transmission of human immunodeficiency virus (HIV)-1 represents a major problem in many regions of the world, especially Southern Africa. With the exception of viral and proviral load, the role for maternal cofactors in perinatal transmission outcome is largely unknown. In this study, an assessment was made of peripheral blood mononuclear cells (PBMC) gene-expression profiles to better understand transcriptional changes associated with HIV-1 infection and perinatal transmission among young adult mothers with infants in Botswana. Peripheral blood mononuclear cells specimens were used from 25 HIV+ drug naive and 20 HIV- healthy mothers, similar in age and location, collected in 1999-2000 and 2003, and processed with the exact same methods, as previously described. Expression profiling of 22 277 microarray gene probes implicated a broad initiation of innate response gene-sets, including toll-like receptor, interferon-stimulated and antiviral RNA response pathways in association with maternal HIV-1 infection. Maternal transmission status was further associated with host genes that influence RNA processing and splicing patterns. In addition to real-time polymerase chain reaction validation of specific genes, enriched category validation of PBMC profiles was conducted using two independent data sets for either HIV-1 infection or an unrelated RNA virus, severe acute respiratory virus infection. HIV-1 pathogen-specific host profiles should prove a useful tool in infection and transmission intervention efforts worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.