ArticleGenes and immunity2006
Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Glycemic Index, Glycemic Load, and FAS rs6586161 Polymorphism in Relation to Gastric Cancer Risk: A Case-Control Study in Korea.Nutrients · 2023Article
- Intercellular Communication in the Islet of Langerhans in Health and Disease.Comprehensive Physiology · 2021Article
- Polymorphisms in the FAS gene are associated with susceptibility to noise-induced hearing loss.Environmental science and pollution research international · 2021Article
- Melatonin Hormone Acts on Cells of Maternal Blood and Placenta From Diabetic Mothers.Frontiers in physiology · 2021Article
- Investigation Trp64Arg polymorphism of the beta 3-adrenergic receptor gene in nonobese women with polycystic ovarian syndrome.International journal of reproductive biomedicine · 2020Article
- Ameliorative Effect and Mechanism of the Purified Anthraquinone-Glycoside Preparation fromMolecules (Basel, Switzerland) · 2019Article
- The role of elevated alanine aminotransferase (ALT), FasL and atherogenic dyslipidemia in type II diabetes mellitus.Journal of Taibah University Medical Sciences · 2017Article
- Fas (CD95) expression in myeloid cells promotes obesity‐induced muscle insulin resistance.EMBO molecular medicine · 2014Article
- Single nucleotide polymorphisms within functional regions of genes implicated in insulin action and association with the insulin resistant phenotype.Molecular and cellular biochemistry · 2011Article
- Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis.The Journal of biological chemistry · 2010Article
- Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice.The Journal of clinical investigation · 2010Article
- The Fas pathway is involved in pancreatic beta cell secretory function.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type II diabetes is caused by a failure of the pancreatic beta-cells to compensate for insulin resistance leading to hyperglycaemia. There is evidence for an essential role of an increased beta-cell apoptosis in type II diabetes. High glucose concentrations induce IL-1beta production in human beta-cells, Fas expression and concomitant apoptosis owing to a constitutive expression of FasL. FASL and FAS map to loci linked to type II diabetes and estimates of insulin resistance, respectively. We have tested two functional promoter polymorphisms, FAS-670 G>A and FASL-844C>T as well as a microsatellite in the 3' UTR of FASL for association to type II diabetes in 549 type II diabetic patients and 525 normal-glucose-tolerant (NGT) control subjects. Furthermore, we have tested these polymorphisms for association to estimates of beta-cell function and insulin resistance in NGT subjects. We found significant association to type II diabetes for the allele distribution of the FASL microsatellite (P-value 0.02, Bonferroni corrected). The FAS-670G>A was associated with homeostasis model assessment insulin resistance index and body mass index (P-values 0.02 and 0.02). We conclude that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects.
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