SynthesisJournal of human hypertension2006
What is the effect of adjusting for more than one measure of current body size on the relation between birthweight and blood pressure?
Synthesis in Journal of human hypertension, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Antenatal Programming of Hypertension: Paradigms, Paradoxes, and How We Move Forward.Current hypertension reports · 2022Review
- Adjustment for time-invariant and time-varying confounders in 'unexplained residuals' models for longitudinal data within a causal framework and associated challenges.Statistical methods in medical research · 2019Article
- Amplification of the association between birthweight and blood pressure with age: the Bogalusa Heart Study.Journal of hypertension · 2010Article
- The relationship between birthweight and longitudinal changes of blood pressure is modulated by beta-adrenergic receptor genes: the Bogalusa Heart Study.Journal of biomedicine & biotechnology · 2010Article
- A structural equation model of the developmental origins of blood pressure.International journal of epidemiology · 2009Article
- Cardiovascular disease in a cohort exposed to the 1940-45 Channel Islands occupation.BMC public health · 2008Article
- Maternal and child undernutrition: consequences for adult health and human capital.Lancet (London, England) · 2008Review
- Simpson's Paradox, Lord's Paradox, and Suppression Effects are the same phenomenon--the reversal paradox.Emerging themes in epidemiology · 2008Article
- Revisiting the interaction between birth weight and current body size in the foetal origins of adult disease.European journal of epidemiology · 2007Article
- Growth, current size and the role of the 'reversal paradox' in the foetal origins of adult disease: an illustration using vector geometry.Epidemiologic perspectives & innovations : EP+I · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The statistical validity of the negative associations observed between birthweight and disease in later life has recently been questioned, because these associations might be due, in part, to inappropriate adjustment for current body size, creating a statistical artefact known as the 'reversal paradox'. The aim of this study was to explore the effect of adjusting for more than one measure of current body size on the association between birthweight and disease in later life using simulations and meta-analyses of empirical studies. The simulations examined the relation between birthweight and adult systolic blood pressure before and after adjusting for one, two or three measures of current body size by including current weight and subsequently adding body mass index and height in successive analytical models. Meta-analyses were then performed to compare the effect sizes observed among empirical studies reporting associations between birthweight and blood pressure before and after adjusting for one or two measures of current body size. The meta-analyses confirmed the results of the simulations - both showed that associations between birthweight and blood pressure tend to become increasingly negative following adjustment for current body size, and that this effect is enhanced after adjusting for additional measures of current body size.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.