ArticleBMC pediatrics2006
Outcome following patent ductus arteriosus ligation in premature infants: a retrospective cohort analysis.
Article in BMC pediatrics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
- The efficiency and safety of low-dose intravenous indomethacin for closure of patent ductus arteriosus in preterm neonate: a randomized controlled trial.Scientific reports · 2025Trial
- Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates.European journal of pediatrics · 2017Trial
- Trial
- Evaluation ofJournal of cardiovascular development and disease · 2026Article
- Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study.BMC pediatrics · 2021Article
- Patent ductus arteriosus treatment trends and associated morbidities in neonates.Scientific reports · 2021Article
- Assessing Patent Ductus Arteriosus (PDA) Significance on Cardiac Output by Whole-Body Bio-impedance.Pediatric cardiology · 2020Article
- Transcatheter Closure of Patent Ductus Arteriosus in Infants With Weight Under 1,500 Grams.Frontiers in pediatrics · 2020Review
- Maternal, fetal and perinatal factors associated with necrotizing enterocolitis in Sweden. A national case-control study.PloS one · 2018Article
- Neonatal Patent Ductus Arteriosus Ligation Operations Performed by Adult Cardiac Surgeons.The Korean journal of thoracic and cardiovascular surgery · 2017Article
- Observational
- Bedside PDA ligation in premature infants less than 28 weeks and 1000 grams.Journal of cardiothoracic surgery · 2016Article
- Outcomes of primary ligation of patent ductus arteriosus compared with secondary ligation after pharmacologic failure in very-low-birth-weight infants.Pediatric cardiology · 2014Article
- Postnatal risk factors associated with hearing loss among high-risk preterm infants: tertiary center results from Turkey.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2014Article
- Effect of surgical subspecialty training on patent ductus arteriosus ligation outcomes.Pediatric surgery international · 2014Article
- Patent ductus arteriosus ligation and adverse outcomes: causality or bias?Journal of clinical neonatology · 2014Review
- Therapeutic strategies, including a high surgical ligation rate, for patent ductus arteriosus closure in extremely premature infants in a North American centre.Paediatrics & child health · 2012Article
- Adrenal function in newborns undergoing surgery.Journal of perinatology : official journal of the California Perinatal Association · 2010Article
- Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2010Article
- Late morbidity during childhood and adolescence in previously premature neonates after patent ductus arteriosus closure.Pediatric cardiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe patent ductus arteriosus (PDA) is an important problem in premature infants. Surgical PDA ligation is usually only be considered when medical treatment has either failed or was contraindicated. The aims of our study were to determine the mortality and morbidity following patent ductus arteriosus ligation in premature infants, and whether prostaglandin synthetase inhibitor (PSI) use prior to ligation affects outcome.
methodsA retrospective case note review study to determine the outcome of premature infants undergoing patent ductus arteriosus ligation in one tertiary neonatal intensive care unit and two paediatric cardiothoracic centres.
resultsWe had follow-up data on 87 infants. Cumulative mortality rates at 7 days, 30 days and at hospital discharge were 2%, 8% and 20% respectively. The incidence of chronic lung disease, intraventricular haemorrhage, necrotising enterocolitis and retinopathy of prematurity were 77%, 39%, 26% and 28% respectively. There was no difference in mortality, incidence of chronic lung disease or duration of oxygen dependence between those who had and those who had not received a PSI prior to surgical ligation. In those who had received 2 or more courses of PSI prior to surgical ligation, there was a trend to increase in the duration of oxygen therapy and chronic lung disease, but no difference in mortality.
conclusionThis study shows that patent ductus arteriosus ligation is a relatively safe procedure (30 day survival 92%) but there is substantial late mortality and a high incidence of morbidity in the survivors. 2 or more courses of PSI prior to surgical ligation trends to increased oxygen dependence and chronic lung disease. This high risk population requires careful follow-up. A definitive prospective cohort study is lacking.
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