ArticleDrug safety2006
Adverse reactions induced by NSAIDs and antibacterials: analysis of spontaneous reports from the Sicilian regional database.
Article in Drug safety, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology.Molecular diversity · 2022Article
- Serious liver injury induced by Nimesulide: an international collaborative study.Archives of toxicology · 2021Article
- Nimesulide induced leukocytoclastic vasculitis and hepatitis: a case report.SpringerPlus · 2015Article
- Amoxicillin/Clavulanic Acid-induced thrombocytopenia.Hospital pharmacy · 2014Article
- The profile of voluntary reported adverse drug reactions at a tertiary care hospital: a fifteen month prospective study.Journal of clinical and diagnostic research : JCDR · 2012Article
- Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?World journal of gastroenterology · 2010Review
- Anaphylactoid reaction considered ciprofloxacin related: a case report and literature review.Clinical therapeutics · 2010Review
- Information about ADRs explored by pharmacovigilance approaches: a qualitative review of studies on antibiotics, SSRIs and NSAIDs.BMC clinical pharmacology · 2009Review
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo (i) evaluate the suspected adverse drug reactions (ADRs) related to NSAIDs and antibacterials that were reported to Sicilian local health officers by healthcare professionals; and (ii) to detect new or serious potential signals of alarm related to these two widely used drug categories.
methodsWe selected all the spontaneous reports of ADRs sent between January 1998 and June 2004 and analysed those attributed to NSAIDs and systemic antibacterials, applying proportional reporting ratio (PRR) methodology. PRRs >2, chi(2) >4 and >3 ADRs were regarded as signals.
resultsDuring the period considered, 1585 reports of ADRs were received overall (42.6% serious), with an annual reporting rate of approximately 49.1 reports per million inhabitants on average; 351 referred to systemic antibacterials, and 179 to NSAIDs. There were 174 (49.6%) reports of serious ADRs associated with antimicrobials and 108 (60.3%) associated with NSAIDs. Disproportionality was observed, in particular for anaphylactic shock induced by ceftriaxone (all reports were associated with off-label use of the drug), photosensitivity reaction induced by lomefloxacin (administered in the summer), hepatitis induced by nimesulide (three cases leading to liver transplantation) and vasculitis induced by nimesulide.
conclusionOur analysis highlighted several signals of alarm deserving further investigation or measures to influence prescribing. This study underlines the value of a regional centre in identifying local factors (such as prescribing patterns) that may increase the prevalence of serious ADRs.
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