ReviewDrug safety2006
Effects of maternally administered drugs on the fetal and neonatal kidney.
Review in Drug safety, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07595302 (Comparing Pain Improvement for Intravenous Versus Oral Acetaminophen in Acute Pelvic Pain), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing Pain Improvement for Intravenous Versus Oral Acetaminophen in Acute Pelvic Pain: A Randomized, Double-Blind, Double-Dummy Controlled Trial (PIVOTAL Trial)
Who cites it
19 citing papers in PubMed, 78 citations in OpenAlex.
- Impact of maternal health on neonatal and long-term kidney outcomes.Pediatric nephrology (Berlin, Germany) · 2026Review
- Secondary Pharmacology Targets for Pediatric Developmental Safety Assessment of New Drugs: Clinical Pharmacology Considerations.Clinical pharmacology and therapeutics · 2026Review
- Machine learning prediction of pediatric adverse drug reactions using consensus-derived scarce data.Communications chemistry · 2025Article
- Do Major Pharmacovigilance Databases Support Evidence of Second Trimester NSAID and Third Trimester Paracetamol Fetotoxicity?Pharmaceuticals (Basel, Switzerland) · 2024Article
- Doxorubicin-Induced Fetal Mesangial Cell Death Occurs Independently of TRPC6 Channel Upregulation but Involves Mitochondrial Generation of Reactive Oxygen Species.International journal of molecular sciences · 2021Article
- Overlap of vitamin A and vitamin D target genes with CAKUT-related processes.F1000Research · 2021Article
- Therapeutic Drug Monitoring Is a Feasible Tool to Personalize Drug Administration in Neonates Using New Techniques: An Overview on the Pharmacokinetics and Pharmacodynamics in Neonatal Age.International journal of molecular sciences · 2020Review
- Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition.Nutrients · 2020Article
- Detection and quantitation of non-steroidal anti-inflammatory drug use close to the time of birth using umbilical cord tissue.Toxicology reports · 2020Article
- Article
- Evaluation of Fetal and Maternal Vancomycin-Induced Kidney Injury during Pregnancy in a Rat Model.Antimicrobial agents and chemotherapy · 2019Article
- Is NSAID use in children associated with the risk of renal injury?Paediatrics & child health · 2019Article
- Acute kidney injury in the fetus and neonate.Seminars in fetal & neonatal medicine · 2017Review
- The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Environmental factors for the development of fetal urinary malformations.World journal of pediatrics : WJP · 2014Review
- Developmental origins of chronic renal disease: an integrative hypothesis.International journal of nephrology · 2013Review
- Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues.Pediatric nephrology (Berlin, Germany) · 2011Review
- PharmGKB summary: very important pharmacogene information for angiotensin-converting enzyme.Pharmacogenetics and genomics · 2010Article
- Sepsis and pregnancy: do we know how to treat this situation?Revista Brasileira de terapia intensivaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of pregnant women and women of childbearing age who are receiving drugs is increasing. A variety of drugs are prescribed for either complications of pregnancy or maternal diseases that existed prior to the pregnancy. Such drugs cross the placental barrier, enter the fetal circulation and potentially alter fetal development, particularly the development of the kidneys. Increased incidences of intrauterine growth retardation and adverse renal effects have been reported. The fetus and the newborn infant may thus experience renal failure, varying from transient oligohydramnios to severe neonatal renal insufficiency leading to death. Such adverse effects may particularly occur when fetuses are exposed to NSAIDs, ACE inhibitors and specific angiotensin II receptor type 1 antagonists. In addition to functional adverse effects, in utero exposure to drugs may affect renal structure itself and produce renal congenital abnormalities, including cystic dysplasia, tubular dysgenesis, ischaemic damage and a reduced nephron number. Experimental studies raise the question of potential long-term adverse effects, including renal dysfunction and arterial hypertension in adulthood. Although neonatal data for many drugs are reassuring, such findings stress the importance of long-term follow-up of infants exposed in utero to certain drugs that have been administered to the mother.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.