ArticleJournal of materials science. Materials in medicine2006
Preparation and characterisation of calcium-phosphate porous microspheres with a uniform size for biomedical applications.
Article in Journal of materials science. Materials in medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Artificial ligaments in anterior cruciate ligament reconstruction: Coating strategies for PET-based materials.Journal of orthopaedic translation · 2025Review
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- Synthesis of Chitosan and Ferric-Ion (FeBiomimetics (Basel, Switzerland) · 2024Article
- Synthesis and Characterization of Calcium Alginate-Based Microspheres Entrapped with TiOPharmaceutics · 2022Article
- Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size.Bioactive materials · 2022Article
- Multiple Porous Synthetic Bone Graft Comprising EngineeredMicro-Channel for Drug Carrier and Bone Regeneration.Materials (Basel, Switzerland) · 2021Article
- Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integrationBioactive materials · 2021Article
- The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite bone substitute.Scientific reports · 2020Article
- Modular microcarrier technologies for cell-based bone regeneration.Journal of materials chemistry. B · 2020Review
- EDTA and NTA Effectively Tune the Mineralization of Calcium Phosphate from Bulk Aqueous Solution.Biomimetics (Basel, Switzerland) · 2017Article
- Injectable hybrid system for strontium local delivery promotes bone regeneration in a rat critical-sized defect model.Scientific reports · 2017Article
- Microsphere-Based Scaffolds in Regenerative Engineering.Annual review of biomedical engineering · 2017Review
- Development of microspheres for biomedical applications: a review.Progress in biomaterials · 2015Article
- Semi-quantitative monitoring of confluence of adherent mesenchymal stromal cells on calcium-phosphate granules by using widefield microscopy images.Journal of materials science. Materials in medicine · 2014Article
- Calcium Orthophosphate-Based Bioceramics.Materials (Basel, Switzerland) · 2013Review
- Nanocrystalline spherical hydroxyapatite granules for bone repair: in vitro evaluation with osteoblast-like cells and osteoclasts.Journal of materials science. Materials in medicine · 2013Article
- The use of micro- and nanospheres as functional components for bone tissue regeneration.Tissue engineering. Part B, Reviews · 2012Review
- Drug-loaded porous spherical hydroxyapatite granules for bone regeneration.Journal of materials science. Materials in medicine · 2011Article
- Calcium orthophosphates as bioceramics: state of the art.Journal of functional biomaterials · 2010Article
- Characterization of polymeric solutions as injectable vehicles for hydroxyapatite microspheres.AAPS PharmSciTech · 2010Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present work, a novel route for the preparation of porous ceramic microspheres is described. Two ceramic powders, calcium-titanium-phosphate (CTP) and hydroxyapatite (HAp), were mixed with a sodium alginate solution that enabled the preparation of spherical particles, using the droplet extrusion method combined with ionotropic gelation in the presence of Ca(2+). The spherical particles were subsequently sintered, to burn-off the polymer and obtain calcium-phosphate microspheres with a uniform size and an interconnected porous network. CTP microspheres with diameters ranging from 513 +/- 24 microm to 792 +/- 35 microm and with pores of approximately 40 microm were obtained. HAp microspheres presented diameters of 429 +/- 46 microm and 632 +/- 40 microm and pores of ca. 2 microm. Depending on the formulations tested, the structure of both calcium phosphates may become altered during the sintering process, suggesting that the ratio between the ceramic phase and the polymer solution is a critical parameter. Porous microspheres prepared using the described methodology are promising candidates as bone defect fillers and scaffolds for bone tissue regeneration.
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