ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 59 citations in OpenAlex.
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- Population genetics and evolutionary history of the endangered Eld's deer (Rucervus eldii) with implications for planning species recovery.Scientific reports · 2021Article
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- Genetic correlations between cartilage regeneration and degeneration reveal an inverse relationship.Osteoarthritis and cartilage · 2020Article
- Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Enhanced cartilage repair in 'healer' mice-New leads in the search for better clinical options for cartilage repair.Seminars in cell & developmental biology · 2017Review
- A link between thrifty phenotype and maternal care across two generations of intercrossed mice.PloS one · 2017Article
- Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides.BMC genomics · 2015Article
- Regeneration of articular cartilage in healer and non-healer mice.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.Heredity · 2014Article
- Molecular insight into the association between cartilage regeneration and ear wound healing in genetic mouse models: targeting new genes in regeneration.G3 (Bethesda, Md.) · 2013Article
- Deconstructing Mus gemischus: advances in understanding ancestry, structure, and variation in the genome of the laboratory mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Review
- Milk ejection in mice LG/J x SM/J.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Quantitative trait loci affecting liver fat content in mice.G3 (Bethesda, Md.) · 2012Article
- Heritability of articular cartilage regeneration and its association with ear wound healing in mice.Arthritis and rheumatism · 2012Article
- Article
- Hypothalamic expression of Peg3 gene is associated with maternal care differences between SM/J and LG/J mouse strains.Brain and behavior · 2012Article
- Genetic architecture of nest building in mice LG/J × SM/J.Frontiers in genetics · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
A new set of LGXSM recombinant inbred (RI) strains is presented. The RI strain panel consists of 18 remaining strains of the original 55 founding strains. Strain characterization is based on 506 polymorphic microsatellites and 4,289 single nucleotide polymorphisms (SNPs) distributed across the genome. Average microsatellite inter-marker distance is 4.80+/-4.84 Mb or 2.91+/-3.21 F(2) cM. SNPs are more densely spaced at 0.57+/-1.27 Mb. Ninety-five percent of all microsatellite inter-marker intervals are separated by less than 15.00 Mb or 8.50 F(2) cM, while 95% of the SNPs are less than 0.95 Mb apart. Strains show expected low levels of nonsyntenic association among loci and complete genomic independence. During inbreeding, the RI strains went through strong natural selection on the agouti locus on Chromosome 2, especially when the epistatically interacting tyrosinase locus on Chromosome 7 carried the wild-type allele. The LG/J and SM/J strains differ in a large number of biomedically important traits, and they and their inter-cross progeny have been used in multiple mapping studies. The LGxSM RI strain panel provides a powerful new resource for mapping the genetic bases of complex traits and should prove to be of great biomedical utility in modeling complex human diseases such as obesity and diabetes.
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