ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Analysis of the MCMV resistome by ENU mutagenesis.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Murine Models of Familial Cytokine Storm Syndromes.Advances in experimental medicine and biology · 2024Review
- Antibiotics, Multidrug-Resistant Bacteria, and Antibiotic Resistance Genes: Indicators of Contamination in Mangroves?Antibiotics (Basel, Switzerland) · 2021Review
- Host genetic susceptibility to viral infections: the role of type I interferon induction.Genes and immunity · 2020Review
- LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.Science (New York, N.Y.) · 2019Article
- Increased Viral Dissemination in the Brain and Lethality in MCMV-Infected, Dicer-Deficient Neonates.Viruses · 2015Article
- Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy.American journal of physiology. Heart and circulatory physiology · 2014Article
- Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives.Genes · 2014Review
- Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation.The Journal of pharmacology and experimental therapeutics · 2014Article
- Quantitative genetics in the study of virus-induced disease.Advances in virus research · 2014Review
- Use of in vivo imaging to monitor the progression of experimental mouse cytomegalovirus infection in neonates.Journal of visualized experiments : JoVE · 2013Article
- Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands.Journal of medicinal chemistry · 2013Article
- ENU-induced phenovariance in mice: inferences from 587 mutations.BMC research notes · 2012Article
- Dissecting immunity by germline mutagenesis.Immunology · 2012Review
- Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα.Nature immunology · 2012Article
- Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.Journal of virology · 2012Article
- A novel ENU-mutation in ankyrin-1 disrupts malaria parasite maturation in red blood cells of mice.PloS one · 2012Article
- Identifying host factors that regulate viral infection.PLoS pathogens · 2012Article
- IFNγ inhibits the cytosolic replication of Shigella flexneri via the cytoplasmic RNA sensor RIG-I.PLoS pathogens · 2012Article
- Resisting viral infection: the gene by gene approach.Current opinion in virology · 2011Review
- Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells.PLoS pathogens · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The mouse cytomegalovirus (MCMV) resistome is the set of host genes with nonredundant functions in resistance to MCMV infection. By screening 3,500 G(3) germline mutant mice ( approximately 1,750 gamete equivalents), we have identified eight transmissible mutations that create MCMV susceptibility in C57BL/6 mice. Among these, a mutation called Domino was noted to cause macrophage susceptibility to vesicular stomatitis virus (VSV) in vitro. This accessory phenotype was not corrected by type I interferon (IFN), which suggested a defect of the type I IFN pathway. Domino corresponds to a point mutation that alters the DNA binding domain of STAT1, leading to a defect of STAT1 activation. Identification of the Domino mutation demonstrates that an in vivo MCMV susceptibility screen is feasible and illustrates how it can provide insight into the resistome. Moreover, some mutations are far more deleterious than Domino in MCMV-infected mice, consistent with the interpretation that certain protein(s) unrelated to IFN production or signaling are more important than IFNs with regard to their net antiviral effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.