ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Chromosome 2 locus Nidd5 has a potent effect on adiposity in the TSOD mouse.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders.JCI insight · 2023Article
- Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains.PloS one · 2014Article
- Roles of activin receptor-like kinase 7 signaling and its target, peroxisome proliferator-activated receptor γ, in lean and obese adipocytes.Adipocyte · 2013Article
- Article
- Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice.Journal of lipid research · 2012Article
- Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Preventive effect of pine bark extract (flavangenol) on metabolic disease in Western diet-loaded tsumura suzuki obese diabetes mice.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Preventive Effect of Boiogito on Metabolic Disorders in the TSOD Mouse, a Model of Spontaneous Obese Type II Diabetes Mellitus.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice.Journal of natural medicines · 2011Article
- Article
- Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata.Journal of natural medicines · 2010Article
- A growth QTL (Pbwg1) region of mouse chromosome 2 contains closely linked loci affecting growth and body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
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4 authors.
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Abstract
We previously reported a quantitative trait locus for body weight, non-insulin-dependent diabetes 5 (Nidd5), on Chromosome 2 in the TSOD (Tsumura, Suzuki, Obese Diabetes) mouse, a model of polygenic obese type 2 diabetes. To find the gene responsible for a specific component of the pathogenesis, we used a marker-assisted selection protocol to produce congenic strains. These mice are designed to carry a control BALB/cA-derived genomic interval and a TSOD background to look for loss of phenotype. One of the strains with the widest congenic interval, D2Mit297-D2Mit304, showed reductions in both body weight and adiposity compared with TSOD mice. The phenotypic analyses of other congenic strains further narrowed the locus in a 9.4-Mb interval between D2Mit433 and D2Mit91, around which numerous loci for body weight and adiposity have been mapped previously. Although the locus showed a relatively modest effect on body weight, it had a major influence on fat mass that explains approximately 60% of the difference in the adipose index between parental TSOD and BALB/cA mice. Furthermore, the congenic strain with a minimal BALB/cA-derived region showed significantly smaller cell sizes of white and brown adipocytes compared with the control littermates. However, the locus did not primarily affect food consumption, general activity, or rectal temperature after cold exposure, although there are clear differences in these traits between the parental strains. The present work physically delineates the major locus for adiposity in the TSOD mouse.
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